Amino acids are critical nutrients that contribute to metabolic and signalling pathways required to meet energy and biosynthetic demands in T cells. A new study now demonstrates that LCK can sense intracellular asparagine to support T cell receptor-mediated CD8+ T cell activation and effector responses to pathogens and tumours.

中文翻译：

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LCK感知天冬酰胺激活T细胞

氨基酸是至关重要的营养素，有助于满足T细胞的能量和生物合成需求所需的代谢和信号传导途径。现在一项新的研究表明，LCK可以感知细胞内的天冬酰胺，以支持T细胞受体介导的CD8 + T细胞活化以及效应物对病原体和肿瘤的反应。