ABSTRACT

Hepatitis E virus (HEV) infection is an emerging zoonotic viral disease, with an increasingly international public health challenge. Despite the concerns that the global disease burden may be underestimated. Therefore, evaluation of the disease epidemiology in South – eastern Asia through a systematic review will assist in unraveling the burden of the disease in the subregion. A priori protocol was prepared for the systematic review and followed by a literature search involving five electronic databases. Identified publications were screened for high quality studies and the elimination of bias and relevant data extracted. A total of 4157 citations were captured, and only 35 were included in the review. A wide range of HEV seroprevalence was recorded from 2% (urban blood donors in Malaysia) to 77.7% (lowland communities in Lao PDR). Sporadic HEV infection and epidemics were also detected in the subregion. Indicating hyperendemicity of the disease in South – eastern Asia.

摘要

戊型肝炎病毒 (HEV) 感染是一种新出现的人畜共患病毒性疾病，其面临的国际公共卫生挑战日益严峻。尽管担心全球疾病负担可能被低估。因此，通过系统评价对东南亚的疾病流行病学进行评估将有助于阐明该次区域的疾病负担。为系统评价准备了先验方案，然后进行了涉及五个电子数据库的文献检索。筛选出已确定的出版物以进行高质量研究并消除偏倚并提取相关数据。总共捕获了 4157 次引文，其中只有 35 次被纳入审查。记录了广泛的 HEV 血清阳性率，从 2%（马来西亚的城市献血者）到 77.7%（老挝人民民主共和国的低地社区）。该次区域还发现了零星的 HEV 感染和流行病。表明该疾病在东南亚高度流行。