Abstracts

U1 snRNP is one of the most abundant ribonucleoprotein (RNP) complexes in eukaryotic cells, and is estimated to be approximately 1 million copies per cell. Apart from its canonical role in mRNA splicing, this complex has emerged as a key regulator of eukaryotic mRNA length via inhibition of mRNA 3ʹ-end processing at numerous intronic polyadenylation sites (PASs), in a process that is also termed U1 snRNP telescripting. Several reviews have extensively described the concept of U1 telescripting, and subsequently highlighted its potential impacts in mRNA metabolism. Here, we review what is currently known regarding the underlying mechanisms of this important phenomenon, and discuss open questions and future challenges.

摘要

U1 snRNP是真核细胞中最丰富的核糖核蛋白（RNP）复合物之一，估计每个细胞大约有100万个拷贝。除了在mRNA剪接中的典型作用外，该复合物还通过抑制许多内含子聚腺苷酸化位点（PASs）的mRNA 3′末端加工而成为真核mRNA长度的关键调节剂，这一过程也被称为U1 snRNP电报。一些评论广泛地描述了U1脚本的概念，并随后强调了它对mRNA代谢的潜在影响。在这里，我们回顾了有关这一重要现象的潜在机制的当前已知知识，并讨论了未解决的问题和未来的挑战。