Abstract

For the first time a new flavonoid compound is isolated from the seeds of Celastrus paniculatus (CP) using different chromatographic techniques and it’s structure is predicted as “3-(3,4-dimethoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one” by employing various spectroscopic studies. The neuroprotective potential of this flavonoid was evaluated against ketamine-induced cognitive deficits with special reference to cholinergic system in vivo. The compound has exhibited significant neuroprotective property against ketamine-induced cholinergic alterations in different brain regions of rat which are restored to normal during the treatment with the compound on par with the reference compound, clozapine. Moreover, the isolated compound was found to be non-toxic to the animal during the treatment which indicates its safety in any human health related applications and can add value to the new drug development. In conclusion, this is the first study of new flavonoid compound of CP and its protective efficacy against schizophrenia.

摘要

首次使用不同的色谱技术从pan草（CP）种子中分离出一种新的类黄酮化合物，其结构预测为“ 3-（3,4-二甲氧基苯基）-1-（4-甲氧基苯基）prop-2 -en-1个”通过采用各种光谱学研究。评估了这种类黄酮对氯胺酮引起的认知功能障碍的神经保护潜力，并特别参考了体内胆碱能系统。该化合物对氯胺酮诱导的大鼠不同脑区胆碱能改变具有显着的神经保护作用，在与参考化合物氯氮平同等治疗的过程中，该改变恢复正常。此外，发现分离的化合物在治疗过程中对动物无毒，这表明它在任何与人类健康有关的应用中都是安全的，并且可以为新药开发增加价值。总之，这是新的CP类黄酮化合物及其对精神分裂症的保护作用的首次研究。