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TIMING OF ACUTE PASSIVE HEATING ON GLUCOSE TOLERANCE AND BLOOD PRESSURE IN PEOPLE WITH TYPE 2 DIABETES: A RANDOMIZED, BALANCED CROSSOVER, CONTROL TRIAL
Journal of Applied Physiology ( IF 3.3 ) Pub Date : 2021-01-07 , DOI: 10.1152/japplphysiol.00747.2020
Thomas J James 1, 2 , Jo Corbett 1 , Michael Cummings 2 , Sharon Allard 2 , John S Young 3 , Jonathan Towse 3 , Kathryn Carey-Jones 4, 5 , Clare Eglin 1 , Billy Hopkins 1 , Connor Morgan 1 , Michael Tipton 1 , Zoe L Saynor 1, 2 , Anthony I Shepherd 1, 2
Affiliation  

Type 2 diabetes mellitus (T2DM) is characterized by chronic hyperglycemia and progressive insulin resistance, leading to macro and microvascular dysfunction. Passive heating has potential to improve glucose homeostasis and act as an exercise mimetic. We assessed the effect of acute passive heating before or during an oral glucose tolerance test (OGTT) in people with T2DM. Twelve people with T2DM were randomly assigned to 3 conditions:1) 3 h OGTT (CON); 2) 1 h passive heating (40 °C water) 30 min before an OGTT (HOT-OGTT); and 3) 1 h passive heating (40 °C water) 30 min after commencing an OGTT (OGTT-HOT). Blood [glucose], insulin sensitivity, extracellular heat shock protein 70 (eHSP70), total energy expenditure (TEE), heart rate (HR), systolic (SBP) and diastolic blood pressure (DBP) were recorded. Passive heating did not alter blood [glucose] (CON, 1,677 (386) a.u.; HOT-OGTT, 1,797 (340) a.u.; OGTT-HOT, 1,662 (364) a.u.; P = 0.28), insulin sensitivity (P = 0.15), or SBP (P = 0.18), but did increase [eHSP70] in both heating conditions (CON, 203.48 (110.81) pg·mL-1; HOT-OGTT, 402.47 (79.02) pg·mL-1; OGTT-HOT, 310.00 (60.53) pg·mL-1; P < 0.001), increased TEE (via fat oxidation) in the OGTT-HOT condition (CON, 263 (33) kcal; HOT-OGTT, 278 (40) kcal; OGTT-HOT, 304 (38) kcal;P = 0.001), increased HR in both heating conditions (P < 0.001) and reduced DBP in OGTT-HOT condition (P < 0.01). Passive heating in close proximity to a glucose challenge does not alter glucose tolerance but does increase [eHSP70] and TEE, and reduce blood pressure in people with T2DM.

中文翻译:

急性被动加热对2型糖尿病患者糖耐量和血压的影响:随机,均衡的交叉,控制试验

2型糖尿病(T2DM)的特征是慢性高血糖症和进行性胰岛素抵抗,导致大血管和微血管功能障碍。被动加热具有改善葡萄糖动态平衡的潜力,并可以作为运动模拟。我们在T2DM患者中进行口服葡萄糖耐量测试(OGTT)之前或期间评估了急性被动加热的效果。十二个T2DM患者被随机分配到3种情况:1)3 h OGTT(CON);2)在OGTT(HOT-OGTT)前30分钟进行1 h被动加热(40°C的水);和3)开始OGTT(OGTT-HOT)后30分钟进行1 h被动加热(40°C水)。记录血液[葡萄糖],胰岛素敏感性,细胞外热休克蛋白70(eHSP70),总能量消耗(TEE),心率(HR),收缩压(SBP)和舒张压(DBP)。-1 ; HOT-OGTT,402.47(79.02)pg·mL -1;OGTT-HOT,310.00(60.53)pg·mL -1;P <0.001),在OGTT-HOT条件下(TE,263(33)kcal; HOT-OGTT,278(40)kcal; OGTT-HOT,304(38)kcal; TEE(通过脂肪氧化)增加。P = 0.001),两种加热条件下的HR升高(P <0.001),OGTT-HOT条件下的DBP降低(P <0.01)。接近葡萄糖挑战的被动加热不会改变葡萄糖耐受性,但会增加[eHSP70]和TEE,并降低患有T2DM人群的血压。
更新日期:2021-01-08
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