Most of acute pancreatitis (AP) are mild and self‐limiting, however, 15%–20% of patients develop severe acute pancreatitis (SAP) or moderately acute pancreatitis (MSAP) with local or systemic complications. Infection complications (ICs) result in 40%–70% morbidity and high mortality rates among SAP and MSAP patients. It is more important to early recognize of ICs of MSAP or SAP. Several studies have indicated that serum soluble programmed cell death protein (sPD‐1) or programmed cell death 1 ligand (sPD‐L1) levels were higher in patients with severe sepsis than in healthy volunteers and have a predictive capacity for mortality. However, the role of serum sPD‐1/sPD‐L1 in AP remains unclear. This study aimed to investigate whether the ICs of AP patients is associated with their sPD‐1 and sPD‐L1 levels, which were determined via enzyme‐linked immunosorbent assay of peripheral blood samples from 63 MSAP and SAP patients and 30 healthy volunteers.

中文翻译：

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血清可溶性PD-1在预测急性胰腺炎患者感染并发症中发挥作用

大多数急性胰腺炎（AP）是轻度和自限性的，然而，15%~20%的患者会出现严重急性胰腺炎（SAP）或中度急性胰腺炎（MSAP）并伴有局部或全身并发症。感染并发症 (IC) 导致 SAP 和 MSAP 患者 40%–70% 的发病率和高死亡率。早期识别MSAP或SAP的IC更为重要。多项研究表明，严重脓毒症患者的血清可溶性程序性细胞死亡蛋白 (sPD-1) 或程序性细胞死亡 1 配体 (sPD-L1) 水平高于健康志愿者，并且具有预测死亡率的能力。然而，血清 sPD-1/sPD-L1 在 AP 中的作用仍不清楚。本研究旨在调查 AP 患者的 IC 是否与其 sPD-1 和 sPD-L1 水平相关，