1 NANOPARTICLE FOR TARGETING CARTILAGE IN OSTEOARTHRITIS

Current treatments for osteoarthritis are limited in their ability to penetrate and persist within the cartilage matrix; furthermore, existing therapies primarily focus on managing pain and modulating joint function as opposed to therapeutic treatment. As such, there is a considerable need for the development of new therapeutics and delivery systems to treat osteoarthritis by slowing, stopping, or reversing the progression of the disease. In this issue of Bioengineering & Translational Medicine, a team led by Professor Liangfang Zhang from the Department of NanoEngineering, Department of Chemical Engineering, and the Moores Cancer Center at the University of California San Diego describes a polymer–lipid hybrid nanoparticle that encapsulates a model drug (MK‐8722) to activate proteins that regulate the metabolism of chondrocytes in the cartilage. These nanoparticles also: (i) display peptides that bind to collagen, thereby improving targeting to cartilage, and (ii) provide controlled release of the model drug, thereby providing a sustained therapeutic effect. After characterizing this nanoparticle for size, surface properties, loading, and release and confirming that the collagen‐targeted nanoparticle enhances retention in cartilage in vivo in mice, the authors demonstrated that the collagen‐targeted nanoparticle provided maintenance of 95% of the cartilage content in an osteoarthritis model compared to 83% for the nontargeted nanoparticle and 60% for the phosphate‐buffered saline‐negative control. Overall, the collagen‐targeted nanoparticles highlight the potential of using drug delivery platforms to overcome challenges related to the targeting and retention of drugs in cartilage.

DOI: 10.1002/btm2.10187

中文翻译：

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BioTM Buzz（第6卷，第1期）

1靶向骨关节炎的纳米颗粒

目前对骨关节炎的治疗在软骨基质中的渗透和持续能力有限。此外，与疗法相反，现有疗法主要集中于控制疼痛和调节关节功能。因此，迫切需要开发新的疗法和递送系统，以通过减慢，停止或逆转疾病的进展来治疗骨关节炎。在本期《生物工程与转化医学》中由加利福尼亚大学圣地亚哥分校的纳米工程系，化学工程系和摩尔癌症中心的张良芳教授领导的团队描述了一种聚合物-脂质杂化纳米粒子，该纳米粒子包裹了可激活的模型药物（MK-8722）调节软骨中软骨细胞代谢的蛋白质。这些纳米颗粒还：（i）展示结合胶原的肽，从而改善对软骨的靶向，和（ii）提供模型药物的受控释放，从而提供持续的治疗效果。在表征了该纳米颗粒的大小，表面性质，负载和释放并确认以胶原蛋白为目标的纳米颗粒增强了小鼠体内软骨的保留后，作者证明以胶原蛋白为靶标的纳米颗粒在骨关节炎模型中可维持95％的软骨含量，相比之下，非靶向性纳米颗粒为83％，磷酸盐缓冲液阴性对照为60％。总体而言，以胶原蛋白为靶标的纳米颗粒突出显示了使用药物递送平台克服与软骨中药物靶向和保留相关的挑战的潜力。

DOI：10.1002 / btm2.10187