OBJECTIVE The purpose of this prospective study was to identify predictive factors of the evolution of the number of seizures. METHODS We included 85 individuals with a diagnosis of Psychogenic Nonepileptic Seizure (PNES) who completed at least two clinical interviews spaced by 6 months during a 24-month follow-up. Participants underwent a structured interview with an experimented clinician in PNES to complete standardized evaluation and validated scales. We collected sociodemographic and clinical data on PNES (number of seizures, duration of the disease), anxiety, depression, history of traumas, alexithymia, dissociation, and post-traumatic stress disorder (PTSD). We used a multivariate linear regression analysis to predict the characteristics independently associated with the evolution of the number of seizures in percentage. RESULTS Dissociation score was significantly associated with a negative evolution of the number of seizures (p < 0.002). Conversely, the diagnosis of PTSD at inclusion was correlated to a positive evolution of the number of seizures (p < 0.029). CONCLUSION Dissociation was related to a more pejorative evolution of the number of seizures while PTSD diagnosis was associated with a decreased number of seizures. It is therefore essential to improve detection and treatment of post-traumatic dissociation. Further studies are required to understand the impact of PTSD on the evolution of the number of seizures.

中文翻译：

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创伤后因素参与 PNES 患者癫痫发作次数的演变

目的 本前瞻性研究的目的是确定癫痫发作次数演变的预测因素。方法 我们纳入了 85 名被诊断为心因性非癫痫发作 (PNES) 的人，他们在 24 个月的随访期间完成了至少两次间隔 6 个月的临床访谈。参与者在 PNES 中与经过试验的临床医生进行结构化访谈，以完成标准化评估和验证量表。我们收集了关于 PNES（癫痫发作次数、疾病持续时间）、焦虑、抑郁、创伤史、述情障碍、分离和创伤后应激障碍 (PTSD) 的社会人口学和临床数据。我们使用多元线性回归分析来预测与癫痫发作次数的演变独立相关的特征（以百分比表示）。结果 解离评分与癫痫发作次数的负演变显着相关（p < 0.002）。相反，纳入时对 PTSD 的诊断与癫痫发作次数的积极演变相关（p < 0.029）。结论 分离与癫痫发作次数的贬义演变有关，而 PTSD 诊断与癫痫发作次数减少有关。因此，必须改进对创伤后分离的检测和治疗。需要进一步的研究来了解 PTSD 对癫痫发作次数演变的影响。结论 分离与癫痫发作次数的贬义演变有关，而 PTSD 诊断与癫痫发作次数减少有关。因此，必须改进对创伤后分离的检测和治疗。需要进一步的研究来了解 PTSD 对癫痫发作次数演变的影响。结论 分离与癫痫发作次数的贬义演变有关，而 PTSD 诊断与癫痫发作次数减少有关。因此，必须改进对创伤后分离的检测和治疗。需要进一步的研究来了解 PTSD 对癫痫发作次数演变的影响。