In late 2019, the new Coronavirus has been identified in the city of Wuhan then COVID-19 spreads like wildfire in the rest of the world. Pregnant women represent a risk category for increased abortion rates and vertical transmission with adverse events on the newborns has been recently confirmed. The scientific world is struggling for finding an effective cure for counteracting symptomatology. Today, there are many therapeutic proposes but none of them can effectively counteract the infection. Moreover, many of these compounds show important side effects not justifying their use. Scientific literature reports an immune system over-reaction through interleukins-6 activation. In this regard, the possibility to control the immune system represents a possible strategy for counteracting the onset of COVID-19 symptomatology. Vitamin D deficiency shows increased susceptibility to acute viral respiratory infections. Moreover, Vitamin D seems involved in host protection from different virus species by modulating activation and release of cytokines. Myo-inositol down-regulates the expression of IL-6 by phosphatidyl-inositol-3-kinase (PI3K) pathway. Furthermore, myo-inositol is the precursor of phospholipids in the surfactant and it is applied for inducing surfactant synthesis in infants for treating respiratory distress syndrome (RDS). This review aims to summarize the evidence about COVID-19 infection in pregnant women and to encourage the scientific community to investigate the use of Vitamin D and Myo-inositol which could represent a possible preventive treatment for pregnant women or women undergoing assisted reproductive technologies (ART).

在2019年末，新的冠状病毒在武汉市被发现，然后COVID-19像野火一样在世界其他地方传播。最近已确认孕妇是流产率增加和垂直传播以及新生儿不良事件的危险类别。科学界正在努力寻找有效的方法来对抗症状。如今，有许多治疗方案，但没有一个能够有效抵消感染。而且，许多这些化合物显示出重要的副作用，不能证明其合理使用。科学文献报道了通过白介素6激活引起的免疫系统反应过度。在这方面，控制免疫系统的可能性代表了抵消COVID-19症状发作的可能策略。维生素D缺乏症显示出对急性病毒性呼吸道感染的敏感性增加。此外，维生素D似乎通过调节细胞因子的激活和释放参与了宿主对不同病毒物种的保护。肌醇通过磷脂酰肌醇-3-激酶（PI3K）途径下调IL-6的表达。此外，肌醇是表面活性剂中磷脂的前体，它被用于诱导婴儿中的表面活性剂合成，以治疗呼吸窘迫综合征（RDS）。这篇综述旨在总结有关孕妇中COVID-19感染的证据，并鼓励科学界对维生素D和肌醇的使用进行调查，这可能是对孕妇或正在接受辅助生殖技术的妇女进行的预防性治疗（ART ）。