Low birthweight and being born small-for-gestational age (SGA) are linked to asthma and impaired lung function. Particularly, poor intrauterine growth followed by rapid catch-up growth during childhood may predispose for respiratory disease. Bronchial hyperresponsiveness (BHR) is an essential feature of asthma, but how foetal and early childhood growth are associated with BHR is less studied. Our hypothesis was that children born SGA or with accelerated early life growth have increased BHR and altered lung function at 11-years of age.

We studied the associations between SGA and early childhood growth with lung function and BHR at 11-years of age in a subgroup of 468 children from the Norwegian Mother, Father and Child Cohort Study (MoBa), and included data from the Medical Birth Registry of Norway (MBRN).

Weight at 6 months of age was positively associated with forced vital capacity (adjusted Beta: 0.121; 95% Confidence interval: 0.023, 0.219) and negatively associated with the ratio of forced expiratory flow in first second/forced vital capacity (−0.204; −0.317, −0.091) at 11-years of age. Similar patterns were found for weight at 36 months and for change in weight from birth to 6 months of age. SGA or other various variables of early childhood growth were not associated with BHR at 11-years of age.

Early life growth was associated with an obstructive lung function pattern, but not with BHR in 11-year old children. Foetal growth restriction or weight gain during early childhood do not seem to be important risk factors for subsequent BHR in children.

低出生体重和小于胎龄 (SGA) 与哮喘和肺功能受损有关。特别是，宫内生长不良以及儿童时期的快速追赶性生长可能容易导致呼吸道疾病。支气管高反应性 (BHR) 是哮喘的一个基本特征，但胎儿和幼儿生长与 BHR 之间的关系的研究较少。我们的假设是，出生时患有 SGA 或早期生长加速的儿童在 11 岁时 BHR 增加并改变了肺功能。

我们在挪威母亲、父亲和儿童队列研究 (MoBa) 的 468 名儿童亚组中研究了 SGA 和儿童早期生长与肺功能和 11 岁时 BHR 之间的关联，并纳入了来自挪威医学出生登记处的数据。挪威（MBRN）。

6月龄时的体重与用力肺活量呈正相关（调整后的贝塔值：0.121；95%置信区间：0.023、0.219），与第一秒用力呼气流量/用力肺活量之比呈负相关（−0.204；− 0.317，-0.091）11岁时。36 个月时的体重以及从出生到 6 个月时的体重变化也发现了类似的模式。SGA 或其他儿童早期生长的各种变量与 11 岁时的 BHR 无关。

早期生命生长与阻塞性肺功能模式相关，但与 11 岁儿童的 BHR 无关。幼儿时期的胎儿生长受限或体重增加似乎并不是儿童随后发生 BHR 的重要危险因素。