Sodium saccharin (SS) is usually used in the field of synthetic sweeter food processing. Excessive consumption of SS may cause many health problems. Therefore, it is very necessary to achieve rapid and highly sensitive detection of SS. Here, method based on surface enhanced Raman scattering (SERS) effect using high density ordered gold wrapped polystyrene spheres (Au@PSs) composite plasmonic nanoparticle arrays as substrate, can achieve quantitative detection of SS in aqueous solution within a certain concentration range. The gap distance between two adjacent Au@PSs can be well controlled. Such arrays are fabricated by a magnetron sputtering deposition method on ordered separated PSs arrays manufactured through reactive ion etching (RIE) method. Due to the high density of sub-10 nm gaps contained in such arrays, the structure exhibits strong SERS activity. Finite difference time domain (FDTD) method calculation also confirms that the fabricated substrate possess enhanced electromagnetic field at the gap site. SERS measurement shows that the limit of detection (LoD) for SS is 10⁻⁷ M, which is far below the national standard (≤5 mg/kg ≈ 2.07 × 10⁻⁵ M). Further study shows a good linear relationship between SERS peak intensity and SS concentration in the range of 10⁻⁷ M～10⁻³ M. This study provides a new and highly sensitive SERS substrate for the simple, rapid, low cost and highly efficient detection of the SS.

糖精钠（SS）通常用于合成甜味食品加工领域。过量摄入SS可能会导致许多健康问题。因此，非常需要实现对SS的快速，高度灵敏的检测。在此，基于表面增强拉曼散射（SERS）效应的方法，以高密度有序金包裹的聚苯乙烯球（Au @ PSs）复合等离子体纳米颗粒阵列为底物，可以实现一定浓度范围内水溶液中SS的定量检测。两个相邻的Au @ PS之间的间隙距离可以很好地控制。通过磁控溅射沉积法在通过反应离子蚀刻（RIE）方法制造的有序分离的PS阵列上制造这样的阵列。由于此类阵列中包含的亚10纳米间隙的高密度，该结构具有很强的SERS活性。时域有限差分（FDTD）方法的计算也证实了所制造的基板在间隙处具有增强的电磁场。SERS测量显示SS的检出限（LoD）为10^-7 M，远低于国家标准（≤5mg / kg≈2.07×10 ^-5 M）。进一步的研究显示了良好的线性在10的范围内SERS峰强度和SS浓度之间关系^-7 M〜10 ^-3 M.本研究为简单的一个新的和高度敏感的SERS衬底，快速，低成本和高效率的检测SS。