Burn injury is one of the most common physical injuries in clinic. It is a big challenge to find an ideal treatment for burn injury. Mesenchymal stem cells (MSCs) have been suggested as a promising candidate for wound healing. However, it is critical to improve the therapeutic efficiency of MSCs for treatment of burn injury. Here, we demonstrated that overexpression of caveolin-1, the main component of the caveolae plasma membranes, promoted the proliferation of MSCs both in vitro and in vivo. Moreover, transplantation of MSCs overexpressing caveolin-1 facilitated the expression of various growth factors and immunoregulatory cytokines and accelerated deep second-degree burn wound healing in a rat model of burn injury. Our results suggest that overexpression of caveolin-1 can improve the therapeutic efficiency of MSCs, which may be a promising strategy for the treatment of deep second-degree burn injury in clinic.

烧伤是临床上最常见的身体伤害之一。找到一种理想的烧伤治疗方法是一个巨大的挑战。间充质干细胞（MSCs）已被建议为伤口愈合的有希望的候选人。然而，提高MSC治疗烧伤的治疗效率至关重要。在这里，我们证明了caveolin-1（caveolae质膜的主要成分）的过表达在体外和体内都促进了MSC的增殖。。此外，在大鼠烧伤模型中，过度表达caveolin-1的MSCs的移植促进了各种生长因子和免疫调节细胞因子的表达，并促进了深二度烧伤创面的愈合。我们的结果表明，caveolin-1的过表达可以提高MSC的治疗效率，这可能是临床上治疗深层二级烧伤的有前途的策略。