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Development and validation of a novel mail-in semen analysis system and the correlation between one hour and delayed semen analysis testing
Fertility and Sterility ( IF 6.7 ) Pub Date : 2021-01-01 , DOI: 10.1016/j.fertnstert.2020.10.047
Mary K Samplaski 1 , Owen Falk 2 , Stanton Honig 3 , David Shin 4 , William Matthews 2 , James F Smith 5
Affiliation  

OBJECTIVE To develop and validate a novel, mail-in semen analysis (SA) system. DESIGN Prospective cohort. SETTING Not applicable. PATIENT(S) Ejaculates from normospermic men. INTERVENTION(S) One-hour SA, then repeat SAs (on same ejaculate) over 52 hours using a novel technique for maintaining sperm viability. MAIN OUTCOME MEASURE(S) World Health Organization SA parameters. RESULT(S) One-hour SA on 104 ejaculates in the validation phase of the study demonstrated normal semen parameters. With up to 52 hours of observation and four subsequent SA measurements/ejaculate, concentration remained stable, motility decreased by 0.39%/h, and normal morphology decreased by 0.1%/h. Measured 1-hour and calculated motility (correlation coefficients 0.87) and morphology (correlation coefficients 0.82) strongly were correlated. CONCLUSION This novel, mail-in, Clinical Laboratory Improvement Amendments-approved SA testing system demonstrates a strong degree of correlation between 1-hour and delayed SA testing. Given the linear motility and morphology decrease and stability of sperm concentration, this test may be used in clinical practice to evaluate semen quality for fertility evaluations. Furthermore, this approach significantly improves the ease, comfort, and efficiency of obtaining a SA, likely breaking down early barriers to accessing successfully a male fertility evaluation.

中文翻译:

一种新型邮寄精液分析系统的开发和验证以及一小时和延迟精液分析测试之间的相关性

目的 开发和验证一种新颖的邮寄精液分析 (SA) 系统。设计 前瞻性队列。设置 不适用。患者从正常精子的男性射精。干预(S) 一小时 SA,然后使用保持精子活力的新技术在 52 小时内重复 SA(在同一次射精上)。主要结果测量 世界卫生组织 SA 参数。结果 在研究的验证阶段对 104 次射精进行 1 小时 SA 显示正常精液参数。通过长达 52 小时的观察和随后的四次 SA 测量/射精,浓度保持稳定,运动性下降 0.39%/h,正常形态下降 0.1%/h。测量的 1 小时和计算的运动性(相关系数 0.87)和形态学(相关系数 0.82)密切相关。结论这本小说,邮寄,临床实验室改进修正案批准的 SA 测试系统表明 1 小时和延迟 SA 测试之间存在很强的相关性。鉴于精子浓度的线性运动和形态下降和稳定性,该测试可用于临床实践中评估精液质量以评估生育能力。此外,这种方法显着提高了获得 SA 的容易度、舒适度和效率,可能会打破成功获得男性生育力评估的早期障碍。该测试可用于临床实践以评估精液质量以进行生育力评估。此外,这种方法显着提高了获得 SA 的容易度、舒适度和效率,可能会打破成功获得男性生育力评估的早期障碍。该测试可用于临床实践以评估精液质量以进行生育力评估。此外,这种方法显着提高了获得 SA 的容易度、舒适度和效率,可能会打破成功获得男性生育力评估的早期障碍。
更新日期:2021-01-01
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