SARS-COV-2 infection represents the greatest pandemic of the world, counting daily increasing number of subjects positive to the virus and, sadly, increasing number of deaths. Current studies reported that the cytokine/chemokine network is crucial in the onset and maintenance of the “cytokine storm”, the event occurring in those patients in whom the progression of COVID-19 will progress, in most cases, to a very severe and potentially threatening disease. Detecting a possible “immune signature” in patients, as assessed by chemokines status in patients with COVID-19, could be helpful for individual risk stratification for developing a more or less severe clinical course of the disease. The present review is specifically aimed at overviewing current evidences provided by in vitro and in vivo studies addressing the issue of which chemokines seems to be involved, at least at present, in COVID-19. Currently available experimental and clinical studies regarding those chemokines more deeply studied in COVID-19, with a specific focus on their role in the cytokine storm and ultimately with their ability to predict the clinical course of the disease, will be taken into account. Moreover, similarities and differences between chemokines and cytokines, which both contribute to the onset of the pro-inflammatory loop characterizing SARS-COV-2 infection, will be briefly discussed. Future studies will rapidly accumulate in the next months and their results will hopefully provide more insights as to the complex physiopathology of COVID-19-related cytokine storm. This will likely make the present review somehow “dated” in a short time, but still the present review provides an overview of the scenario of the current knowledge on this topic.

SARS-COV-2 感染代表了世界上最大的流行病，每天都有越来越多的病毒呈阳性的受试者，不幸的是，死亡人数也在增加。目前的研究报告说，细胞因子/趋化因子网络对于“细胞因子风暴”的发生和维持至关重要，“细胞因子风暴”发生在那些 COVID-19 进展的患者身上，在大多数情况下，这些事件会发展到非常严重且可能威胁疾病。通过 COVID-19 患者的趋化因子状态评估，检测患者可能存在的“免疫特征”可能有助于对个体风险进行分层，以确定该病的临床病程或多或少严重。本综述专门旨在概述体外和体内提供的当前证据研究解决了 COVID-19 似乎涉及哪些趋化因子的问题，至少目前是这样。目前可用的关于那些在 COVID-19 中更深入研究的趋化因子的实验和临床研究将被考虑在内，特别关注它们在细胞因子风暴中的作用以及最终预测疾病临床过程的能力。此外，将简要讨论趋化因子和细胞因子之间的异同，它们都有助于促炎循环的发生，而促炎循环是 SARS-COV-2 感染的特征。未来的研究将在未来几个月迅速积累，其结果有望为 COVID-19 相关细胞因子风暴的复杂生理病理学提供更多见解。这可能会使本评论在短时间内以某种方式“过时”，