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Effects of Chronic Photobiomodulation with Transcranial Near-Infrared Laser on Brain Metabolomics of Young and Aged Rats
Molecular Neurobiology ( IF 5.1 ) Pub Date : 2021-01-08 , DOI: 10.1007/s12035-020-02247-z
Fabrízio Dos Santos Cardoso 1, 2 , Júlio César Claudino Dos Santos 3 , Francisco Gonzalez-Lima 2 , Bruno Henrique Silva Araújo 4 , Rodrigo Álvaro Brandão Lopes-Martins 5 , Sérgio Gomes da Silva 1, 6, 7
Affiliation  

Since laser photobiomodulation has been found to enhance brain energy metabolism and cognition, we conducted the first metabolomics study to systematically analyze the metabolites modified by brain photobiomodulation. Aging is often accompanied by cognitive decline and susceptibility to neurodegeneration, including deficits in brain energy metabolism and increased susceptibility of nerve cells to oxidative stress. Changes in oxidative stress and energetic homeostasis increase neuronal vulnerability, as observed in diseases related to brain aging. We evaluated and compared the cortical and hippocampal metabolic pathways of young (4 months old) and aged (20 months old) control rats with those of rats exposed to transcranial near-infrared laser over 58 consecutive days. Statistical analyses of the brain metabolomics data indicated that chronic transcranial photobiomodulation (1) significantly enhances the metabolic pathways of young rats, particularly for excitatory neurotransmission and oxidative metabolism, and (2) restores the altered metabolic pathways of aged rats towards levels found in younger rats, mainly in the cerebral cortex. These novel metabolomics findings may help complement other laser-induced neurocognitive, neuroprotective, anti-inflammatory, and antioxidant effects described in the literature.



中文翻译:

经颅近红外激光慢性光生物调节对青年和老年大鼠脑代谢组学的影响

由于已经发现激光光生物调节可以增强大脑能量代谢和认知,我们进行了第一次代谢组学研究,以系统地分析大脑光生物调节修饰的代谢物。衰老通常伴随着认知能力下降和神经变性的易感性,包括脑能量代谢缺陷和神经细胞对氧化应激的易感性增加。正如在与脑老化相关的疾病中所观察到的那样,氧化应激和能量稳态的变化会增加神经元的脆弱性。我们评估并比较了年轻(4 个月大)和老年(20 个月大)对照大鼠与连续 58 天暴露于经颅近红外激光的大鼠的皮质和海马代谢途径。脑代谢组学数据的统计分析表明,慢性经颅光生物调节 (1) 显着增强年轻大鼠的代谢途径,特别是兴奋性神经传递和氧化代谢,以及 (2) 将老年大鼠改变的代谢途径恢复到年轻大鼠的水平,主要在大脑皮层。这些新的代谢组学发现可能有助于补充文献中描述的其他激光诱导的神经认知、神经保护、抗炎和抗氧化作用。

更新日期:2021-01-08
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