Multimodal in-situ experiments are the wave of the future, as this approach will permit multispectral data collection and analysis during real-time nanoscale observation. In contrast, the evolution of technique development in the electron microscopy field has generally trended toward specialization and subsequent bifurcation into more and more niche instruments, creating a challenge for reintegration and backward compatibility for in-situ experiments on state-of-the-art microscopes. We do not believe this to be a requirement in the field; therefore, we propose an adaptive instrument that is designed to allow nearly simultaneous collection of data from aberration-corrected transmission electron microscopy (TEM), probe-corrected scanning transmission electron microscopy, ultrafast TEM, and dynamic TEM with a flexible in-situ testing chamber, where the entire instrument can be modified as future technologies are developed. The value would be to obtain a holistic understanding of the underlying physics and chemistry of the process-structure–property relationships in materials exposed to controlled extreme environments. Such a tool would permit the ability to explore, in-situ, the active reaction mechanisms in a controlled manner emulating those of real-world applications with nanometer and nanosecond resolution. If such a powerful tool is developed, it has the potential to revolutionize our materials understanding of nanoscale mechanisms and transients.

中文翻译：

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集成透射电子显微镜的可能性：实现复杂的原位实验

多模态原位实验是未来的潮流，因为这种方法将允许在实时纳米级观察期间进行多光谱数据收集和分析。相比之下，电子显微镜领域技术发展的演变总体上趋向于专业化，随后分叉成越来越多的利基仪器，这对最先进显微镜原位实验的重新整合和向后兼容性提出了挑战. 我们不认为这是该领域的要求；因此，我们提出了一种自适应仪器，旨在允许几乎同时收集来自像差校正透射电子显微镜 (TEM)、探针校正扫描透射电子显微镜、超快 TEM 和具有灵活原位测试室的动态 TEM 的数据, 随着未来技术的发展，整个仪器可以被修改。其价值在于全面了解暴露于受控极端环境的材料的过程-结构-性能关系的潜在物理和化学。这种工具将允许以受控方式在原位探索活性反应机制，模拟具有纳米和纳秒分辨率的现实世界应用的机制。如果开发出如此强大的工具，它就有可能彻底改变我们对纳米级机制和瞬态的材料理解。其价值在于全面了解暴露于受控极端环境的材料的过程-结构-性能关系的潜在物理和化学。这种工具将允许以受控方式在原位探索活性反应机制，模拟具有纳米和纳秒分辨率的现实世界应用的机制。如果开发出如此强大的工具，它就有可能彻底改变我们对纳米级机制和瞬态的材料理解。其价值在于全面了解暴露于受控极端环境的材料的过程-结构-性能关系的潜在物理和化学。这种工具将允许以受控方式在原位探索活性反应机制，模拟具有纳米和纳秒分辨率的现实世界应用的机制。如果开发出如此强大的工具，它就有可能彻底改变我们对纳米级机制和瞬态的材料理解。