Autoimmune hepatitis (AIH) is a chronic hepatitis of unknown etiology and several cytokines have been implicated in its pathogenesis and onset. Our objective was to determine the profile of pro and anti-inflammatory cytokines, including IL-1β, IL-6, IL-8, IL-23, IFN-γ, TNF-α, IL-10 in autoimmune hepatitis and their association with HLA gene polymorphisms. Serum cytokine levels were determined in 50 autoimmune hepatitis patients and one hundred fifty controls using chemiluminescence and ELISA techniques and HLA genotyping performed by PCR SSP. The levels of IL-6 (12 pg/mL vs. 5.5 pg/mL, p = 0.017), IL-8 (24.1 pg/mL vs. 7.8 pg/mL, p = 0.006), and TNF-α (61.1 pg/mL vs. <4.00 pg/mL, p = 0.002) were significantly higher in AIH patients in pretreatment phase compared to levels after remission and in controls. HLA*DRB15 was significantly associated with higher levels of IL-8. IL-6, IL-8, and TNF-α may be biomarkers of AIH activity. HLA gene expression may play a role in higher cytokine production and could allow an earlier diagnosis and better management of the disease.

自身免疫性肝炎（AIH）是一种病因不明的慢性肝炎，其发病机理和发病机制与多种细胞因子有关。我们的目的是确定自身免疫性肝炎中促炎细胞因子和抗炎细胞因子的概况，包括IL-1β，IL-6，IL-8，IL-23，IFN-γ，TNF-α，IL-10以及它们与HLA基因多态性。使用化学发光和ELISA技术以及通过PCR SSP进行的HLA基因分型，确定了50名自身免疫性肝炎患者和150名对照的血清细胞因子水平。IL-6（12 pg / mL vs. 5.5 pg / mL，p = 0.017），IL-8（24.1 pg / mL vs. 7.8 pg / mL，p = 0.006）和TNF-α（61.1 pg）的水平/ mL与<4.00 pg / mL，p = 0.002）在AIH患者的治疗前期显着高于缓解后和对照组的水平。HLA * DRB15与更高水平的IL-8显着相关。IL-6，IL-8和TNF-α可能是AIH活性的生物标记。HLA基因表达可能在更高的细胞因子产生中发挥作用，并且可以更早地诊断和更好地控制疾病。