In-house fabricated silicon nanoporous membranes (SNMs), functionalized for efficient clearance of uremic toxins, can lead to compact and portable dialysis systems. Efficacy of 15 nm thick SNMs, with average pore diameter of 8 nm, was tested for dialysis of two uremic toxins - urea and creatinine using custom made teflon apparatus of 2, 10 and 30 ml. The apparatus consisted of two reservoirs, with the cis containing the uremic fluid, and the trans containing the dialysate. Peristalsis was found to enhance the clearance rate by a factor of four as compared to unstirred condition. Functionalisation of the SNMs reduced protein binding, and surface binding of urea from 23% to negligible values. A lateral array of nine SNMs and a new design for the dialysis apparatus, increased the clearance rate by a factor of twelve from that of the single SNM. The arrays cleared about 42% of urea and 48% of creatinine from 30 ml of diluted serum samples, in 15 min. Periodic replacement of the trans fluid cleared about 81% of high concentration uremic toxins from the cis reservoir in 45 mins. The SNM arrays are stable, reproducible, and with the superior clearance rates for urea and creatinine, they have the potential to be used as membranes for portable hemodialysers.

内部制造的硅纳米多孔膜 (SNM)，功能化以有效清除尿毒症毒素，可导致紧凑和便携式透析系统。使用定制的 2、10 和 30 毫升聚四氟乙烯装置测试了 15 纳米厚的 SNM，平均孔径为 8 纳米，用于透析两种尿毒症毒素——尿素和肌酐的功效。该装置由两个储液器组成，顺式储液器装有尿毒症液体，反式储液器含有透析液。与未搅拌条件相比，发现蠕动可将清除率提高四倍。SNM 的功能化将蛋白质结合和尿素的表面结合从 23% 降低到可忽略不计的值。九个 SNM 的横向阵列和透析装置的新设计，将清除率从单个 SNM 的清除率提高了 12 倍。阵列在 15 分钟内从 30 毫升稀释的血清样品中清除了约 42% 的尿素和 48% 的肌酐。定期更换反式液体可在 45 分钟内从顺式储存器中清除约 81% 的高浓度尿毒症毒素。SNM 阵列稳定、可重复，并且具有出色的尿素和肌酐清除率，它们有可能用作便携式血液透析仪的膜。