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Inflammatory Fibroid Polyp of the Gastrointestinal Tract: A Systematic Review for a Benign Tumor
In Vivo ( IF 2.3 ) Pub Date : 2021-01-01 , DOI: 10.21873/invivo.12235
Nikolaos Garmpis 1 , Christos Damaskos 2, 3 , Anna Garmpi 4 , Vasiliki E Georgakopoulou 5, 6 , Stratigoula Sakellariou 7 , Aliki Liakea 7 , Dimitrios Schizas 8 , Evangelos Diamantis 9 , Paraskevi Farmaki 10 , Errika Voutyritsa 3 , Athanasios Syllaios 8 , Alexandros Patsouras 11 , Georgia Sypsa 5 , Alexandra Agorogianni 12 , Athanasia Stelianidi 10 , Efstathios A Antoniou 1, 3 , Konstantinos Kontzoglou 1, 3 , Nikolaos Trakas 13 , Dimitrios Dimitroulis 1
Affiliation  

Background/Aim: Inflammatory fibroid polyp (IFP) is a rare, usually solitary and intraluminal polypoid benign tumor that can affect any part of the gastrointestinal (GI) tract, although in the majority of cases it affects the stomach. This lesion is characterized by proliferation of highly vascular fibrous tissue and infiltration by a variable number of different inflammatory cells. Its etiology is unknown. Our aim was to describe all the reported data concerning IFP. Materials and Methods: An extensive search of the PubMed Index was performed for publications with titles or abstracts containing the terms: “inflammatory fibroid polyp” with/without “Vanek”. Results were filtered for publications in English and concerning only humans. One hundred and twenty-four publications were finally included in this review. Results: IFP has a female predominance. It affects patients in their 5th decade of life, although there are cases of patients from 4 to 84 years of age. IFP usually affects the stomach and more specifically the gastric antrum but can be detected throughout the GI tract. A significant number of cases remain asymptomatic but the most frequent presentations of IFP are abdominal pain, acute abdomen and GI bleeding. Most cases are treated by endoscopic resection of the lesion. No recurrence nor IFP-specific complications have been reported. Histopathology of IFP varies. Conclusion: It is relatively safe to conclude that both the etiology and the timing of diagnosis might change the histopathology, immunohistological staining and tissue structure of IFP. Suggested theories should be taken into consideration with caution as the etiology and pathophysiological mechanisms of IFP are unknown.

中文翻译:

胃肠道炎性纤维瘤息肉:良性肿瘤的系统评价

背景/目的:炎性肌瘤息肉 (IFP) 是一种罕见的、通常为孤立性和腔内息肉样良性肿瘤,可影响胃肠道 (GI) 的任何部分,但在大多数情况下会影响胃部。这种病变的特点是高度血管纤维组织的增殖和不同数量的不同炎症细胞的浸润。其病因不明。我们的目的是描述所有有关 IFP 的报告数据。材料和方法:对 PubMed 索引进行了广泛搜索,以查找标题或摘要包含以下术语的出版物:“炎性纤维瘤息肉”,有/无“Vanek”。结果被过滤为英语出版物并且仅涉及人类。一百二十四篇出版物最终被纳入本次审查。结果:IFP 以女性为主。尽管有些患者的年龄在 4 至 84 岁,但它会影响到 50 岁的患者。IFP 通常会影响胃,更具体地说是胃窦,但可以在整个胃肠道中检测到。大量病例仍然无症状,但 IFP 最常见的表现是腹痛、急腹症和胃肠道出血。大多数病例通过内窥镜切除病变进行治疗。没有报告复发或 IFP 特异性并发症。IFP 的组织病理学各不相同。结论:相对安全的结论是,病因和诊断时机都可能改变 IFP 的组织病理学、免疫组织染色和组织结构。
更新日期:2021-01-01
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