Background/Aim: The mechanisms underlying the contribution of the heparan sulfate proteoglycan syndecan-1 to liver tissue injury and to crucial biological processes, such as fibrogenesis, remain to be elucidated. Therefore, we investigated the immunohistochemical expression of syndecan-1 in chronic liver diseases (CLDs) and its probable role in hepatic fibrosis. Materials and Methods: Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue sections of biopsy material obtained from 128 patients diagnosed with CLDs. The correlation between syndecan-1 expression and the stage of fibrosis was investigated. Results: According to the severity of fibrosis, cases were categorized into three groups: early fibrosis; intermediate fibrosis; advanced fibrosis. Syndecan-1 expression was significantly enhanced in advanced fibrosis compared to early (p<0.012) and intermediate (p<0.003) fibrosis. Conclusion: In CLDs, syndecan-1 immunohisto-chemical overexpression was found to be positively correlated with the severity of fibrosis, suggesting its probable role in hepatic fibrogenesis.

中文翻译：

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Syndecan-1 在慢性肝病中的表达：与肝纤维化的相关性

背景/目的：硫酸乙酰肝素蛋白多糖 syndecan-1 对肝组织损伤和关键生物学过程（如纤维化）的作用的机制仍有待阐明。因此，我们研究了 syndecan-1 在慢性肝病 (CLD) 中的免疫组织化学表达及其在肝纤维化中的可能作用。材料和方法：对取自 128 名诊断为 CLD 的患者的活检材料的福尔马林固定、石蜡包埋的组织切片进行免疫组织化学。研究了syndecan-1表达与纤维化阶段之间的相关性。结果：根据纤维化的严重程度，将病例分为三组：早期纤维化；中间纤维化; 晚期纤维化。与早期 (p<0.012) 和中期 (p<0.003) 纤维化相比，晚期纤维化中 Syndecan-1 的表达显着增强。结论：在 CLD 中，syndecan-1 免疫组化过表达与纤维化的严重程度呈正相关，提示其可能在肝纤维化中发挥作用。