An efficient and scalable enone-promoted method for the decarboxylation of trans-4-hydroxy-proline has been developed in flow to provide access to (R)-pyrrolidin-3-ol hydrochloride using biomass-derived isophorone. The advantages of deploying flow in this setting were reinforced by direct comparsion to batch. This method lays a foundation for fossil fuel and ammonia free alternative access to amines on scales relevant to manufacturing.

中文翻译：

---

烯酮促进流动中反式-4-羟基-L-脯氨酸的脱羧：与批次的并排比较

已经开发出有效且可扩展的烯酮促进的反式-4-羟基脯氨酸脱羧方法，以使用生物质衍生的异佛尔酮提供对（R）-吡咯烷-3-醇盐酸盐的访问。通过直接比较批处理，增强了在这种情况下部署流量的优势。该方法奠定了化石燃料和无氨替代胺与生产相关规模的基础。