The presence of depression in people living with HIV/AIDS could lead to non-adherence to antiretroviral medications. It also leads to further comorbid and opportunistic illness and then lowering the patient's quality of life. The objective of this study was therefore to determine the pooled prevalence of depression and its related factors in HIV patients. Relevant articles in PubMed, Scopus, and EMBASE were investigated. The Meta-XL version 5.3 was used to extract data and STATA-11 Meta-prop packages with the Random effect model was used to quantify depression and its related factors. Sensitivity and subgroup analysis were performed to explore sources of heterogeneity. The Cochran’s Q-statistic and the Higgs I2 test were also done. Besides, the Eggers test and symmetry in the funnel plot were used to detect the presence/absence of publication bias. In this meta-analysis, we included 21 articles that assessed 10,090 participants. The average prevalence of depression among people with HIV/AIDS was 35.8% (95% CI 28.29, 43.25). The average estimated prevalence of depressive symptoms was 59.4% in the Oromia region and 29.25% in southern Ethiopia. Besides, the average prevalence of depression was 45.6% and 26.2% as measured with Beck’s depression inventory and Hospital anxiety and depression scale respectively. Moreover, the prevalence of depression was 47.7% in studies that used a sample size ≤ of 400 participants and 28.5% in studies that used a sample size of > 400 participants. The pooled adjusted odds ratio (AOR) of perceived HIV stigma was 3.75 (95% CI 2.34, 5.16) and that of poor social support was 6.22 (95% CI 2.96, 9.47). Moreover, the average odds ratio of poor medication adherence, opportunistic infection, and advanced stages of AIDS were 3.03 (95% CI 1.00, 5.05), 5.5 (95% CI 1.97, 10.03), and 5.43 (95% CI 1.60, 9.28) respectively. The pooled prevalence of depression among individuals living with HIV/AIDS was high. Factors such as perceived HIV stigma, poor social support, opportunistic infection, advanced AIDS stage, and poor medication adherence were related to it. Routine screening and management of depression and its related factors should be given due consideration.

中文翻译：

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在低收入国家埃塞俄比亚，接受抗逆转录病毒治疗的患者的抑郁症状及其决定因素：系统评价和荟萃分析

艾滋病毒/艾滋病感染者的抑郁症可能导致不遵守抗逆转录病毒药物。它还会导致进一步的合并症和机会性疾病，进而降低患者的生活质量。因此，本研究的目的是确定艾滋病毒患者中抑郁的综合患病率及其相关因素。研究了PubMed，Scopus和EMBASE中的相关文章。使用Meta-XL版本5.3提取数据，并使用带有随机效应模型的STATA-11 Meta-prop软件包来量化抑郁症及其相关因素。进行敏感性和亚组分析以探索异质性的来源。还进行了Cochran的Q统计量和Higgs I2检验。除了，使用Eggers检验和漏斗图中的对称性来检测是否存在发布偏倚。在这项荟萃分析中，我们纳入了21篇文章，对10,090名参与者进行了评估。艾滋病毒/艾滋病患者中抑郁症的平均患病率为35.8％（95％CI 28.29，43.25）。估计的抑郁症状患病率在奥罗米亚地区为59.4％，在埃塞俄比亚南部为29.25％。此外，根据贝克的抑郁量表和医院焦虑量表，抑郁症的平均患病率分别为45.6％和26.2％。此外，在样本量≤400名参与者的研究中，抑郁症的患病率为47.7％，在样本量> 400名参与者的研究中为28.5％。感知到的艾滋病毒污名的合并调整后优势比（AOR）为3.75（95％CI 2.34，5。16）和社会支持差的贫困率为6.22（95％CI 2.96，9.47）。此外，药物依从性差，机会感染和艾滋病晚期的平均几率分别为3.03（95％CI 1.00，5.05），5.5（95％CI 1.97，10.03）和5.43（95％CI 1.60，9.28）分别。在艾滋病毒/艾滋病感染者中，抑郁症的合并患病率很高。诸如与艾滋病毒的耻辱感，社会支持差，机会性感染，艾滋病晚期，药物依从性差等因素均与之相关。常规筛查和管理抑郁症及其相关因素应予以适当考虑。43（95％CI 1.60，9.28）。在艾滋病毒/艾滋病感染者中，抑郁症的合并患病率很高。诸如与艾滋病毒的耻辱感，社会支持差，机会性感染，艾滋病晚期，药物依从性差等因素均与之相关。常规筛查和管理抑郁症及其相关因素应予以适当考虑。43（95％CI 1.60，9.28）。在艾滋病毒/艾滋病感染者中，抑郁症的合并患病率很高。诸如与艾滋病毒的耻辱感，社会支持差，机会性感染，艾滋病晚期，药物依从性差等因素均与之相关。常规筛查和管理抑郁症及其相关因素应予以适当考虑。