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Understanding COVID-19 Pandemic: Molecular Mechanisms and Potential Therapeutic Strategies. An Evidence-Based Review
Journal of Inflammation Research ( IF 4.5 ) Pub Date : 2021-01-07 , DOI: 10.2147/jir.s282213
Reem Hanna , Snehal Dalvi , Tudor Sălăgean , Ioana Delia Pop , Ioana Roxana Bordea , Stefano Benedicenti

Abstract: Initially, the SARS-CoV-2 virus was considered as a pneumonia virus; however, a series of peer reviewed medical papers published in the last eight months suggest that this virus attacks the brain, heart, intestine, nervous and vascular systems, as well the blood stream. Although many facts remain unknown, an objective appraisal of the current scientific literature addressing the latest progress on COVID-19 is required. The aim of the present study was to conduct a critical review of the literature, focusing on the current molecular structure of SARS-CoV-2 and prospective treatment modalities of COVID-19. The main objectives were to collect, scrutinize and objectively evaluate the current scientific evidence-based information, as well to provide an updated overview of the topic that is ongoing. The authors underlined potential prospective therapies, including vaccine and phototherapy, as a monotherapy or combined with current treatment modalities. The authors concluded that this review has produced high quality evidence, which can be utilized by the clinical scientific community for future reference, as the knowledge and understanding of the SARS-CoV-2 virus are evolving, in terms of its epidemiological, pathogenicity, and clinical manifestations, which ultimately map the strategic path, towards an effective and safe treatment and production of a reliable and potent vaccine.

Keywords: SARS-CoV-2, COVID-19, virus pathogenicity, cytokines storm, diagnostic methods, immunotherapy, vaccine, antiviral, photobiomodulation therapy, PBMT, photodynamic therapy, PDT, clinical trials


中文翻译:

了解COVID-19大流行:分子机制和潜在的治疗策略。循证审查

摘要:最初,SARS-CoV-2病毒被认为是肺炎病毒。但是,在过去八个月中发表的一系列同行评审医学论文表明,这种病毒攻击了大脑,心脏,肠,神经和血管系统以及血液。尽管许多事实仍然未知,但是需要对评估COVID-19最新进展的当前科学文献进行客观评估。本研究的目的是对文献进行严格的审查,重点是SARS-CoV-2的当前分子结构和COVID-19的前瞻性治疗方式。主要目标是收集,审查和客观评估当前基于科学证据的信息,并提供正在进行的主题的最新概述。作者强调了潜在的前瞻性疗法,包括疫苗和光疗,可作为单一疗法或与当前治疗方式结合使用。作者得出的结论是,由于SARS-CoV-2病毒在流行病学,致病性和致病性方面的知识和理解不断发展,因此该综述产生了高质量的证据,可供临床科学界将来参考。临床表现,最终勾勒出通往有效,安全治疗和生产可靠有效的疫苗的战略道路。

关键词: SARS-CoV-2,COVID-19,病毒致病性,细胞因子风暴,诊断方法,免疫疗法,疫苗,抗病毒,光生物调节疗法,PBMT,光动力疗法,PDT,临床试验
更新日期:2021-01-07
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