Vibrio (V.) vulnificus infection is a rare disease whose death rates exceed 50% despite aggressive antibiotic treatment and surgical debridement. The aim of this study was to assess the ability of specific anti-V. vulnificus immunoglobulins Y (IgYs) for preventing and treating V. vulnificus infections. IgYs were produced by immunizing egg laying hens with inactivated whole cell bacteria. Peritoneal cytokines, blood’s bacterial load, and survival curves were obtained from both prophylactic and therapeutic mouse models. The results showed that the specific IgYs (i) inhibited the growth of V. vulnificus in vitro, (ii) dramatically reduced the inflammatory response and blood’s bacterial load, and (iii) improved the survival rate of V. vulnificus-infected mice. These results prove that anti-V. vulnificus IgYs can be markedly effective means for the prophylaxis and the therapy of V. vulnificus infections.

中文翻译：

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鸡蛋黄免疫球蛋白 (IgY) 对创伤弧菌感染的保护作用

创伤弧菌( V.)感染是一种罕见疾病，尽管采取积极的抗生素治疗和手术清创，死亡率仍超过 50%。本研究的目的是评估特异性抗创伤弧菌免疫球蛋白 Y (IgY) 预防和治疗创伤弧菌感染的能力。IgY 是通过用灭活的全细胞细菌对产蛋母鸡进行免疫而产生的。从预防性和治疗性小鼠模型中获得腹膜细胞因子、血液细菌负荷和生存曲线。结果表明，特异性IgYs（i）在体外抑制创伤弧菌的生长，（ii）显着降低炎症反应和血液细菌载量，以及（iii）提高创伤弧菌感染小鼠的存活率。这些结果证明抗创伤弧菌IgY可以成为预防和治疗创伤弧菌感染的显着有效的手段。