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Neurophysiological and brain structural markers of cognitive frailty differs from Alzheimer's disease
medRxiv - Neurology Pub Date : 2021-01-06 , DOI: 10.1101/2021.01.06.21249338
Ece Kocagoncu , David Nesbitt , Tina Emery , Laura Hughes , Richard N. Henson , James B. Rowe ,

With increasing life span, there is growing importance of understanding the mechanisms of successful cognitive ageing. In contrast, cognitive frailty has been proposed to be a precursor to Alzheimer's disease. Here we test the hypothesis that cognitively frail adults represent a branch of healthy ageing, distinct from latent dementia. We used electro-magnetoencephalography and magnetic resonance imaging to investigate the structural and neurophysiological features of cognitive frailty in relation to healthy aging, and clinical presentations of mild cognitive impairment and Alzheimer's disease. Cognitive performance of the cognitively frail group was similar to those with mild cognitive impairment. We used a novel cross-modal oddball task to induce mismatch responses to unexpected stimuli. Both controls and cognitively frail showed stronger mismatch responses and larger temporal grey matter volume, compared to people with mild cognitive impairment and Alzheimer's disease. Our results suggest that cognitively frail represents a spectrum of normal ageing rather than incipient or undiagnosed Alzheimer's disease. Lower cognitive reserve, hearing impairment and medical comorbidity might contribute to the aetiology of cognitive impairment.

中文翻译:

认知脆弱的神经生理和大脑结构标志物与阿尔茨海默氏病不同

随着寿命的延长,理解成功的认知老龄化的机制变得越来越重要。相反,已经提出认知脆弱是阿尔茨海默氏病的先兆。在这里,我们测试了一个假设,即认知脆弱的成年人代表了健康老龄化的一个分支,与潜在的痴呆症不同。我们使用电磁脑电图和磁共振成像技术来研究与健康衰老相关的认知脆弱的结构和神经生理特征,以及轻度认知障碍和阿尔茨海默氏病的临床表现。认知脆弱组的认知表现与轻度认知障碍者相似。我们使用了一种新颖的跨模态奇异球任务来诱导对意外刺激的不匹配反应。与患有轻度认知障碍和阿尔茨海默氏病的人相比,对照者和认知脆弱者均表现出更强的失配反应和更大的颞灰质量。我们的结果表明,认知脆弱代表了正常衰老的频谱,而不是初期或未诊断的阿尔茨海默氏病。较低的认知储备,听力障碍和医学合并症可能有助于认知障碍的病因。
更新日期:2021-01-07
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