A quarter of a century ago, publication of the 12 Mb genome sequence of Saccharomyces cerevisiae S288C transformed yeast research forever and further cemented the strength and status of this yeast as a versatile laboratory model for eukaryotic cells. Knowledge on the gene complement and genome sequence of S. cerevisiae inspired yeast scientists to address the next challenge: elucidation of the biological functions of all its 6000 genes (Goffeau et al. 1996). This was no trivial challenge, as the sequencing project had just revealed a thousand genes with uncharacterized function.

中文翻译：

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进入 GATTACA：酵母基因组：分析、洞察和应用

25 年前，酿酒酵母S288C的 12 Mb 基因组序列的发表永远改变了酵母研究，并进一步巩固了这种酵母作为真核细胞多功能实验室模型的实力和地位。关于酿酒酵母的基因互补和基因组序列的知识激发了酵母科学家应对下一个挑战：阐明其所有 6000 个基因的生物学功能（Goffeau等人，1996 年）。这不是一个微不足道的挑战，因为测序项目刚刚揭示了具有未表征功能的一千个基因。