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Lower Cord Blood IL-17 and IL-25, but Not Other Epithelial Cell-Derived Cytokines Are Associated with Atopic Dermatitis in Infancy
International Archives of Allergy and Immunology ( IF 2.8 ) Pub Date : 2021-01-07 , DOI: 10.1159/000512919
Cristina Gamez 1, 2 , Jessica Metcalfe 3, 4 , Susan L Prescott 3, 4, 5, 6 , Debra J Palmer 3, 5
Affiliation  

Background: There is a growing need for early biomarkers that may predict the development of atopic dermatitis (AD). As alterations in skin barrier may be a primary event in disease pathogenesis, epithelial cell (EC) cytokines expression patterns may be a potential biomarker in early life to target allergy preventive strategies towards “at-risk” infants. Objectives: The aim of this longitudinal investigation was to examine from birth over the course of infancy levels of the EC cytokines: thymic stromal lymphopoietin (TSLP), interleukin (IL)-33, IL-25, and IL-17 in infants at high-risk of AD due to maternal atopy. Method: We collected (n = 31) cord blood samples from atopic mothers and followed up their infants at 4–6 and 12 months of age for collection of peripheral venous blood samples and diagnosis of AD. TSLP concentration was measured by ELISA after acetone precipitation of the samples. IL-33, IL-25, and IL-17 levels were measured by Luminex. Results: Seven infants who developed AD had lower levels of IL-25 and IL-17 at birth compared to the 24 infants who did not develop AD by 12 months of age. Conclusions: Lower cord blood levels of IL-17 and IL-25, but not other EC cytokines, were associated with the onset of AD during infancy. Our results highlight that the in-utero period appears critical, and potential maternal influences on cord blood EC-derived cytokine concentrations requires further exploration.
Int Arch Allergy Immunol


中文翻译:

较低的脐带血 IL-17 和 IL-25,但不是其他上皮细胞衍生的细胞因子与婴儿期特应性皮炎有关

背景:对可以预测特应性皮炎 (AD) 发展的早期生物标志物的需求日益增长。由于皮肤屏障的改变可能是疾病发病机制的主要事件,上皮细胞 (EC) 细胞因子表达模式可能是生命早期的潜在生物标志物,以针对“高危”婴儿制定过敏预防策略。目标:这项纵向研究的目的是检查从出生到婴儿期 EC 细胞因子的水平:胸腺基质淋巴细胞生成素 (TSLP)、白细胞介素 (IL)-33、IL-25 和 IL-17 在高-由于母体特应性引起的 AD 风险。方法:我们收集( n= 31) 来自特应性母亲的脐带血样本,并在 4-6 个月和 12 个月大时对其婴儿进行随访,以收集外周静脉血样本并诊断 AD。在样品的丙酮沉淀后通过ELISA测量TSLP浓度。IL-33、IL-25 和 IL-17 水平由 Luminex 测量。结果:与在 12 个月大时未患 AD 的 24 名婴儿相比,7 名患 AD 的婴儿在出生时的 IL-25 和 IL-17 水平较低。结论:较低的 IL-17 和 IL-25 脐带血水平,而不是其他 EC 细胞因子,与婴儿期 AD 的发病有关。我们的结果强调,子宫内期似乎很关键,母体对脐带血 EC 衍生细胞因子浓度的潜在影响需要进一步探索。
Int Arch 过敏免疫
更新日期:2021-01-07
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