Pancreatic cancer is a usually fatal disease that needs innovative therapeutic approaches since the current treatments are poorly effective. In this study, based on cell lines, triazole-based coordination trimers made with soluble Fe(II) in an aqueous media were explored for the first time as adjuvant agents for the treatment of this condition. These coordination complexes were effective at relatively high concentrations and led to an increase in reactive oxygen species (ROS) in two pancreatic cancer cell lines, PANC-1 and BXPC-3, and this effect was accompanied by a significant reduction in cell viability in the presence of gemcitabine (GEM). Importantly, the tested compounds enhanced the effect of GEM, an approved drug for pancreatic cancer, through apoptosis induction and downregulation of the mTOR pathway. Although further evaluation in animal-based models of pancreatic cancer is needed, these results open novel avenues for exploring these iron-based materials in biomedicine in general and in pancreatic cancer treatment.

中文翻译：

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水溶性铁基三聚体作为胰腺癌的协同佐剂

胰腺癌是一种通常致命的疾病，由于目前的治疗效果不佳，因此需要创新的治疗方法。在这项研究中，基于细胞系，首次探索了在水介质中用可溶性Fe（II）制成的基于三唑的配位三聚体作为治疗这种疾病的佐剂。这些配位复合物在相对较高的浓度下有效，并导致两种胰腺癌细胞系PANC-1和BXPC-3中的活性氧（ROS）升高，并且这种作用伴随着该细胞中细胞活力的显着降低。吉西他滨（GEM）的存在。重要的是，被测试的化合物通过凋亡诱导和mTOR通路的下调增强了GEM（一种批准用于胰腺癌的药物）的作用。