The purpose of this paper is to investigate the immune function of the tumor microenvironment and its clinical correlation with colonic carcinoma. Immune genes were downloaded from the The Cancer Genome Atlas database. Five subtypes are obtained by cluster screening based on immune gene expression data. The C3 and C4 subtypes show stronger immune activity. In addition, the C4 subtype has the largest number of gene mutations and the worst prognosis. Most of the immune signatures are upregulated in the C4 subtype, while most of the immune infiltration‐related cells are upregulated in the C3 and C4 subtypes. The different immune microenvironments between these subtypes may provide new ideas for immunotherapy strategies in colon carcinoma.

中文翻译：

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两种免疫增强的分子亚型在I–II期结肠癌的炎症，免疫检查点，突变和预后方面存在差异

本文的目的是研究肿瘤微环境的免疫功能及其与结肠癌的临床相关性。免疫基因是从The Cancer Genome Atlas数据库下载的。通过基于免疫基因表达数据的聚类筛选获得五个亚型。C3和C4亚型显示较强的免疫活性。此外，C4亚型的基因突变数量最多，预后最差。大多数免疫特征在C4亚型中上调，而大多数免疫浸润相关细胞在C3和C4亚型中上调。这些亚型之间不同的免疫微环境可能为结肠癌的免疫治疗策略提供新的思路。