The canonical DNA glycosylase role is global base damage repair but includes functions in epigenetic gene regulation, immune response modulation, replication, and transcription. In this issue of Structure, Eckenroth et al. (2020) present the NEIL2 glycosylase structure. Its catalytic domain flexibility differentiates it from most other glycosylases and suggests novel regulatory mechanisms.

中文翻译：

---

打破规则：NEIL2法规中的蛋白质雕刻

规范的DNA糖基化酶的作用是修复整体碱基，但包括表观遗传基因调节，免疫应答调节，复制和转录等功能。在本期《结构》中，Eckenroth等人。（2020）提出了NEIL2糖基化酶结构。它的催化结构域灵活性使其与大多数其他糖基化酶区别开来，并提出了新颖的调节机制。