Background

The virulence of isolates among different Candida species causing candidemia may play a role in the prognosis of the patients. Furthermore, the potential relationship between genotype and virulence is still unclear and need to be further studied.

Aims

We aim to assess the relationship between genotype and virulence in Candida species using a Galleria mellonella larvae infection model.

Methods

One hundred and ninety-four isolates from 68 clusters (Candida albicans, 114/41; Candida parapsilosis, 74/24; Candida tropicalis, 6/3) were compared against the same number of each species singleton genotypes in terms of survival of G. mellonella larvae.

Results

The median of survival and the IQR ranges of clusters and singleton were as follows: C. albicans (2 days, IQR 1.5–2 vs. 2 days, IQR 1–2.25), C. parapsilosis (2 days, IQR 1.5–2.6 vs. 2 days, IQR 2–3.3), and C. tropicalis (1 day, IQR 1–3.5 vs. 2 days, IQR 2–3.5; p < 0.05). High intra-cluster variability in terms of median of survival was found regardless the species.

Conclusions

No relationship between genotype and virulence in Candida was observed with the G. mellonella model.

中文翻译：

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念珠菌属中基因型与毒力之间缺乏相关性

背景

引起念珠菌血症的不同念珠菌种间分离株的毒力可能对患者的预后有影响。此外，基因型与毒力之间的潜在关系仍不清楚，需要进一步研究。

宗旨

我们旨在使用大蜡螟幼虫感染模型评估念珠菌属物种中基因型和毒力之间的关系。

方法

从68簇（一百94株白色念珠菌;，41分之114近平滑念珠菌，74/24;热带念珠菌，6/3）针对的生存期方面相同数目的每个物种单基因型进行比较G.蜜蜡幼虫。

结果

存活中位数和集群和单身的 IQR 范围如下：白色念珠菌（2 天，IQR 1.5-2对2 天，IQR 1-2.25），近平滑念珠菌（2 天，IQR 1.5-2.6对. 2 天，IQR 2-3.3）和热带假丝酵母（1 天，IQR 1-3.5对比2 天，IQR 2-3.5；p  <  0.05）。无论物种如何，都发现在存活中位数方面的集群内变异性很高。

结论

在G. mellonella模型中未观察到念珠菌中基因型和毒力之间的关系。