The pressure conditions are important for performing a variety of ion manipulations in mass spectrometers including ion transfer, ion dissociation and mass analysis. In contrast with lab-scale instruments, miniature mass spectrometers typically have simple configurations and reduced pumping power. In this study, a new design of configuration was implemented for a miniature ion trap mass spectrometer with a discontinuous atmospheric interface, realizing a real-time pressure adjustment within a single scan cycle to obtain optimal performance for different stages in a tandem-in-time mass analysis. Gas introduction from the connection between the turbo and rough pumps was used to elevate the vacuum pressure, with pinch valves and needle valves used to set the levels desirable. Pressures in a wide range from 0.01mtorr to 10mtorr could be set with great adjustability and stability. Multiple MS/MS analyses could be performed using a single ion introduction, with mass-selective ion transfer and collision induced dissociation at 2 mTorr while mass analysis below 0.5 mTorr.

压力条件对于在质谱仪中执行各种离子操作（包括离子转移，离子解离和质量分析）非常重要。与实验室规模的仪器相比，微型质谱仪通常具有简单的配置和降低的泵浦功率。在这项研究中，针对具有不连续大气界面的微型离子阱质谱仪实施了新的配置设计，在单个扫描周期内实现了实时压力调节，从而可以在串联的同时获得最佳性能质量分析。从涡轮泵和粗泵之间的连接处引入的气体被用来提高真空压力，其中夹管阀和针阀用于设定所需的水平。压力范围从0开始。可以将01mtorr设置为10mtorr，具有很好的可调性和稳定性。可以使用单个离子引入进行多个MS / MS分析，其中质量选择离子转移和碰撞诱导的离解为2 mTorr，而质量分析为0.5 mTorr以下。