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A Review on Mesenchymal Stem Cells for Treatment of Retinal Diseases
Stem Cell Reviews and Reports ( IF 4.8 ) Pub Date : 2021-01-06 , DOI: 10.1007/s12015-020-10090-x
Sanjucta Adak 1 , Damaris Magdalene 2 , Saurabh Deshmukh 2 , Dipankar Das 3 , Bithiah Grace Jaganathan 1
Affiliation  

Mesenchymal Stem Cells (MSCs) have been studied extensively for the treatment of several retinal diseases. The therapeutic potential of MSCs lies in its ability to differentiate into multiple lineages and secretome enriched with immunomodulatory, anti-angiogenic and neurotrophic factors. Several studies have reported the role of MSCs in repair and regeneration of the damaged retina where the secreted factors from MSCs prevent retinal degeneration, improve retinal morphology and function. MSCs also donate mitochondria to rescue the function of retinal cells and exosomes secreted by MSCs were found to have anti-apoptotic and anti-inflammatory effects. Based on several promising results obtained from the preclinical studies, several clinical trials were initiated to explore the potential advantages of MSCs for the treatment of retinal diseases. This review summarizes the various properties of MSCs that help to repair and restore the damaged retinal cells and its potential for the treatment of retinal degenerative diseases.



中文翻译:

间充质干细胞治疗视网膜疾病综述

间充质干细胞 (MSCs) 已被广泛研究用于治疗多种视网膜疾病。MSCs 的治疗潜力在于它能够分化成多个谱系和富含免疫调节、抗血管生成和神经营养因子的分泌组。几项研究报告了 MSCs 在受损视网膜修复和再生中的作用,其中 MSCs 分泌的因子可预防视网膜变性,改善视网膜形态和功能。MSCs 还捐赠线粒体来拯救视网膜细胞的功能,并且发现 MSCs 分泌的外泌体具有抗凋亡和抗炎作用。基于从临床前研究中获得的一些有希望的结果,启动了几项临床试验,以探索 MSCs 在治疗视网膜疾病方面的潜在优势。

更新日期:2021-01-07
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