Our aging population is growing and developing treatments for age-related diseases such as Alzheimer’s and Parkinson’s disease has taken on an increasing urgency and is accompanied by high public awareness. The already high and rising incidence of acute kidney injury (AKI) in the elderly, however, has received relatively little attention despite the potentially fatal outcomes associated with an episode of AKI in this age group. When discussing AKI and aging, one should consider two aspects: first, elderly patients have an increased susceptibility to an AKI episode, and second, they have decreased kidney repair after AKI given the high incidence of progression to chronic kidney disease (CKD). It is unclear if the same factors that drive the increased susceptibility to AKI could be playing a role in the decreased repair capacity or if they are totally different and unrelated. This review will examine current knowledge on the risk factors for the increased susceptibility to AKI in the elderly and will also explore potential aspects that might contribute to a decreased kidney repair response in this age group.

我们的人口老龄化正在增长，并且开发与年龄相关的疾病（例如阿尔茨海默氏症和帕金森氏病）的治疗方法越来越紧迫，并且伴随着公众的高度关注。然而，老年人急性肾损伤 (AKI) 的发病率已经很高且不断上升，尽管该年龄组的 AKI 发作可能导致致命的后果，但受到的关注相对较少。在讨论 AKI 和老龄化时，应该考虑两个方面：首先，老年患者对 AKI 发作的易感性增加，其次，考虑到进展为慢性肾脏病 (CKD) 的高发生率，他们在 AKI 后的肾脏修复能力下降。目前尚不清楚导致 AKI 易感性增加的相同因素是否可能在降低修复能力中发挥作用，或者它们是否完全不同且不相关。本综述将检查目前对老年人 AKI 易感性增加的危险因素的了解，并将探讨可能导致该年龄组肾脏修复反应降低的潜在方面。