Purpose/objective

While hypertension is an important contributor to cardiovascular disease (CVD) and its treatment has well-established mortality benefits, there is uncertainty as regards the management of isolated systolic hypertension (ISH). Furthermore, the association of ISH with CVD and mortality has been established, but the metabolic characteristics of the affected population have not as yet been adequately described. The aim of this study was to describe the metabolic profiles of patients with ISH.

Methods

An observational study of patients attending the Hypertension Unit of the University Hospital of Heraklion, Crete, Greece, was performed.

Results

In total, 809 hypertensive patients not on any antihypertensive treatment were identified. Among them, 44.7% were men, aged 55.6 ± 12.5 years, while 29.7% of both men and women were smokers. Systolic blood pressure was 161.3 ± 15.8 mmHg and diastolic blood pressure was 96.1 ± 11.3 mmHg. Body mass index (BMI) was 31 ± 5.3 kg/m², while 9.6% had type 2 diabetes (T2D). A comparison of patients with ISH with those with hypertension, but not ISH, revealed that patients with ISH were older and had lower SBP and higher pulse pressure, while they also had lower total cholesterol and LDL and were more likely to have T2D, albeit they had a slightly lower BMI. On the other hand, they did not have any difference in terms of gender, smoking status, HDL, triglycerides, liver biochemistry, uric acid, or prevalence of impaired fasting glucose.

Conclusion

Patients with ISH were older, with lower SBP, total cholesterol, and LDL and higher pulse pressure and higher prevalence of diabetes.

中文翻译：

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单纯收缩期高血压患者的代谢特征

目的/目标

虽然高血压是心血管疾病 (CVD) 的重要诱因，并且其治疗具有公认的死亡率益处，但孤立性收缩期高血压 (ISH) 的管理仍存在不确定性。此外，ISH 与 CVD 和死亡率的关联已经确定，但受影响人群的代谢特征尚未得到充分描述。本研究的目的是描述 ISH 患者的代谢特征。

方法

对就诊于希腊克里特岛伊拉克利翁大学医院高血压科的患者进行了一项观察性研究。

结果

总共确定了 809 名未接受任何抗高血压治疗的高血压患者。其中，男性占44.7%，年龄55.6±12.5岁，男性和女性吸烟者占29.7%。收缩压为 161.3 ± 15.8 mmHg，舒张压为 96.1 ± 11.3 mmHg。体重指数 (BMI) 为 31 ± 5.3 kg/m ²，而 9.6% 患有 2 型糖尿病 (T2D)。ISH 患者与高血压患者而非 ISH 患者的比较显示，ISH 患者年龄较大，收缩压较低，脉压较高，同时他们的总胆固醇和 LDL 也较低，更可能患有 T2D，尽管他们BMI略低。另一方面，他们在性别、吸烟状况、HDL、甘油三酯、肝脏生化、尿酸或空腹血糖受损的患病率方面没有任何差异。

结论

ISH 患者年龄较大，收缩压、总胆固醇和 LDL 较低，脉压较高，糖尿病患病率较高。