In epidemiological and clinical studies, the restricted mean lifetime is often of direct interest quantity. The differences of this quantity can be used as a basis of comparing several treatment groups with respect to their survival times. When the factor of interest is not randomized and lifetimes are subject to both dependent and independent censoring, the imbalances in confounding factors need to be accounted. We use the mixture of additive hazards model and inverse probability of censoring weighting method to estimate the differences of restricted mean lifetime. The average causal effect is then obtained by averaging the differences fitted values based on the additive hazards models. The asymptotic properties of the proposed method are also derived and simulation studies are conducted to demonstrate their finite-sample performance. An application to the primary biliary cirrhosis (PBC) data is illustrated.

中文翻译：

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在相关审查下使用附加危害模型估计受限平均寿命的差异

在流行病学和临床研究中，受限制的平均寿命通常是直接感兴趣的数量。该数量的差异可用作比较几个治疗组的存活时间的基础。当感兴趣的因素不是随机的并且生命周期受到相关和独立审查时，需要考虑混杂因素的不平衡。我们使用加性风险模型和审查加权方法的逆概率的混合来估计受限平均寿命的差异。然后通过对基于加性风险模型的差异拟合值进行平均来获得平均因果效应。还导出了所提出方法的渐近特性，并进行了模拟研究以证明其有限样本性能。