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A General and Robust Estimation Method for the Case-Time-Control Design
Sociological Methodology ( IF 6.118 ) Pub Date : 2019-07-22 , DOI: 10.1177/0081175019862259
Arvid Sjölander 1 , Yang Ning 2
Affiliation  

The case-time-control design is a tool to control for measured, time-varying covariates that increase montonically in time within each subject while also controlling for all unmeasured covariates that are constant within each subject across time. Until recently, the design was restricted to data with only two timepoints and a single binary covariate, or data with a binary exposure. Sjölander (2017) made an important extension that allows for an arbitrary number of timepoints and covariates and a nonbinary exposure. However, his estimation method requires fairly strong model assumptions, and it may create bias if these assumptions are violated. We propose a novel estimation method for the case-time-control design, which to a large extent relaxes the model assumptions in Sjölander. We show in simulations that this estimation method performs well under a range of scenarios and gives consistent estimates when Sjölander’s estimation does not.

中文翻译:

工况-时间-控制设计的通用且稳健的估计方法

案例时间控制设计是一种工具,用于控制每个受试者内随时间单调增加的测量的、随时间变化的协变量,同时还控制每个受试者内随时间恒定的所有未测量的协变量。直到最近,设计仅限于只有两个时间点和单个二元协变量的数据,或具有二元曝光的数据。Sjölander (2017) 做了一个重要的扩展,允许任意数量的时间点和协变量以及非二元暴露。然而,他的估计方法需要相当强的模型假设,如果违反这些假设,可能会产生偏差。我们为案例时间控制设计提出了一种新的估计方法,这在很大程度上放宽了 Sjölander 中的模型假设。
更新日期:2019-07-22
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