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Efficacy of Pumpkin Ointment in Treatment of Chronic Hand Eczema: A Randomized, Active-Controlled, Double Blind Clinical Trial
Iranian Journal of Public Health ( IF 1.4 ) Pub Date : 2020-07-06 , DOI: 10.18502/ijph.v49i7.3588
Alemeh Khademi 1 , Parvin Mansuri 2 , Daryoush Pahlevan 3 , Mahbubeh Bozorgi 4 , Malihe Nasiri 5 , Somayeh Hejazi 2 , Zahra Azizian 6 , Laila Shirbeigi 1
Affiliation  

Background: Hand Eczema (HE) is chronic skin disease with a high prevalence in population. It has negative impact on the quality of life. Due to the public interest in herbal remedies, we attempt to assess the efficacy of pumpkin ointment in treatment of chronic HE in this research. Methods: This study was conducted in an outpatient clinic at Imam-Khomeini Hospital in Tehran (Iran) from May 2015 to Nov 2016. We performed a double-blind trial on 60 patients with chronic HE randomized to four groups included pumpkin, betamethasone, eucerin and almond ointment (n=15 for each group) for 28 days. Patients were ordered to apply ointments twice a day. Hand Eczema Severity Index (HECSI) and Dermatology Life Quality Index (DLQI) of the patients were evaluated by a dermatologist on the 1st, 14th and 28th d after the start of treatment. Results: Patients’ DLQI scores in pumpkin and betamethasone group was significant and pumpkin group showed a better response in quality of life (P=0.001). Betamethasone and pumpkin ointment were effective and showed significant improvement compared with almond and eucerin and reduce HECSI scores (P=0.002 and P=0.012 respectively). Betamethasone ointment outcome on HECSI scores in comparison with topical pumpkin was significant (P<0.001). No clinically adverse effects were observed. Conclusion: Although pumpkin ointment showed a better response in patients’ DLQI in HE but it was less effective than betamethasone in decreasing HECSI.

中文翻译:

南瓜软膏治疗慢性手部湿疹的疗效:一项随机、主动对照、双盲临床试验

背景:手部湿疹(HE)是一种在人群中高发的慢性皮肤病。它对生活质量产生负面影响。由于公众对草药的兴趣,我们试图在本研究中评估南瓜软膏治疗慢性 HE 的疗效。方法:本研究于 2015 年 5 月至 2016 年 11 月在德黑兰(伊朗)伊玛目霍梅尼医院的门诊进行。我们对 60 名慢性 HE 患者进行了双盲试验,随机分为 4 组,包括南瓜、倍他米松、优色林和杏仁软膏(每组 n = 15),持续 28 天。患者被要求每天两次涂抹药膏。治疗开始后第1、14、28天由皮肤科医生对患者手部湿疹严重程度指数(HECSI)和皮肤科生活质量指数(DLQI)进行评估。结果:南瓜组和倍他米松组患者的DLQI评分有显着性差异,南瓜组的生活质量反应更好(P=0.001)。倍他米松和南瓜软膏效果显着,与杏仁和优色林相比有显着改善,降低了 HECSI 评分(分别为 P=0.002 和 P=0.012)。与局部南瓜相比,倍他米松软膏对 HECSI 评分的结果显着(P<0.001)。未观察到临床不良反应。结论:虽然南瓜软膏对HE患者DLQI的反应较好,但在降低HECSI方面效果不如倍他米松。倍他米松和南瓜软膏效果显着,与杏仁和优色林相比有显着改善,降低了 HECSI 评分(分别为 P=0.002 和 P=0.012)。与局部南瓜相比,倍他米松软膏对 HECSI 评分的结果显着(P<0.001)。未观察到临床不良反应。结论:虽然南瓜软膏对HE患者DLQI的反应较好,但在降低HECSI方面效果不如倍他米松。倍他米松和南瓜软膏效果显着,与杏仁和优色林相比有显着改善,降低了 HECSI 评分(分别为 P=0.002 和 P=0.012)。与局部南瓜相比,倍他米松软膏对 HECSI 评分的结果显着(P<0.001)。未观察到临床不良反应。结论:虽然南瓜软膏对HE患者DLQI的反应较好,但在降低HECSI方面效果不如倍他米松。
更新日期:2020-07-06
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