Objective: To determine whether changes in serum galectin-3 (gal-3) concentrations in schizophrenia patients have etiopathogenetic importance. Since very little research has assessed the connection between galectins and schizophrenia, we wanted to examine alterations in the inflammatory marker gal-3 in schizophrenia and investigate possible correlations between clinical symptomatology and serum concentrations. Methods: Forty-eight schizophrenia patients and 44 healthy controls were included in this study. The Scale for the Assessment of Positive Symptoms (SAPS) and the Scale for the Assessment of Negative Symptoms (SANS) were administered to determine symptom severity. Venous blood samples were collected, and serum gal-3 levels were measured. Results: Mean serum gal-3 levels were significantly lower in schizophrenia patients, and there were no significant differences in age or sex with the control group. There was also a significant positive correlation between serum gal-3 concentrations and negative schizophrenia symptoms according to the SANS. Conclusion: The results indicate that gal-3 is decreased in schizophrenia patients, which could contribute to inflammation in the pathogenesis of schizophrenia.

中文翻译：

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精神分裂症患者血清半乳糖凝集素 3 水平降低

目的：确定精神分裂症患者血清半乳糖凝集素 3 (gal-3) 浓度的变化是否具有病因学重要性。由于很少有研究评估半乳糖凝集素与精神分裂症之间的联系，我们想检查精神分裂症中炎症标志物 gal-3 的变化，并研究临床症状与血清浓度之间可能的相关性。方法：本研究共纳入 48 名精神分裂症患者和 44 名健康对照者。使用阳性症状评估量表 (SAPS) 和阴性症状评估量表 (SANS) 来确定症状严重程度。收集静脉血样，并测量血清gal-3水平。结果：精神分裂症患者的平均血清 gal-3 水平显着降低，并且与对照组在年龄或性别上没有显着差异。根据 SANS，血清 gal-3 浓度与精神分裂症阴性症状之间也存在显着的正相关。结论：结果表明精神分裂症患者中gal-3水平降低，这可能在精神分裂症的发病机制中促进炎症反应。