In recent years, Candida parapsilosis is recognized as a species complex and is composed of Candida parapsilosis sensu stricto, Candida orthopsilosis and Candida metapsilosis. Candida parapsilosis complex prosthetic valve endocarditis (PVE) is rare and the survival rate is still low despite of optimal therapeutic strategies. In our report, it is novel to report cases as Candida parapsilosis complex PVE at species and identify Candida parapsilosis using MALDI-TOF MS. Case presentation A series of 4 cases of Candida parapsilosis complex PVE from our institution was reported. Three were infected by Candida parapsilosis sensu stricto and one was infected by Candida metapsilosis. The condition of two cases got better and the other died. More attention should be paid to Candida parapsilosis complex PVE and early diagnosis and prompt antibiotic therapy may play a role in the treatment for Candida parapsilosis complex PVE. It is recommended to identify Candida parapsilosis complex at species level and MALDI-TOF MS as an easy, fast and efficient identification method is worth promoting in clinical microbiology

中文翻译：

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一系列药物治疗近平滑念珠菌复杂人工瓣膜心内膜炎

近年来，近平滑念珠菌被认为是一个物种复合体，由狭义近平滑念珠菌、正平滑念珠菌和变形念珠菌组成。近平滑念珠菌复合体人工瓣膜心内膜炎 (PVE) 很少见，尽管采用了最佳治疗策略，但存活率仍然很低。在我们的报告中，将病例报告为物种近平滑念珠菌复合 PVE 并使用 MALDI-TOF MS 识别近平滑念珠菌是新颖的。病例介绍 报告了我们机构的 4 例近平滑念珠菌复合型 PVE 病例。3 人感染了严格的近平滑念珠菌，1 人感染了变平滑念珠菌。两例病情好转，另一例死亡。近平滑念珠菌复合型PVE应引起更多关注，早期诊断和及时抗生素治疗可能在近平滑念珠菌复合型PVE的治疗中发挥作用。推荐在物种水平上鉴定近平滑念珠菌复合体，MALDI-TOF MS作为一种简便、快速、高效的鉴定方法，值得在临床微生物学中推广