Abstract

Background:

Having accurate, up-to-date information on the epidemiology of mild cognitive impairment (MCI) and dementia is imperative.

Objective:

To determine the prevalence of MCI and dementia in Norway using data from a large population-based study.

Methods:

All people 70 + years of age, n = 19,403, in the fourth wave of the Trøndelag Health Study (HUNT4) were invited to participate in the study HUNT4 70 + . Trained health personnel assessed participants using cognitive tests at a field station, at homes, or at their nursing home. Interviewers also completed a structured carer questionnaire in regard to participants suspected of having dementia. Clinical experts made diagnoses according to DSM-5 criteria. We calculated prevalence weighing the data to ensure population representativeness.

Results:

A total of 9,930 (51.1%) of the possible 19,403 people participated, and 9,663 of these had sufficient information for analysis. Standardized prevalence of dementia and MCI was 14.6% (95% confidence interval (CI) 13.9–15.4) and 35.3% (95% CI 34.3–36.4), respectively. Dementia was more prevalent in women and MCI more prevalent in men. The most prevalent dementia subtype was Alzheimer’s disease (57%). By adding data collected from a study of persons ≤70 years in the same region, we estimate that there are 101,118 persons with dementia in Norway in 2020, and this is projected to increase to 236,789 and 380,134 in 2050 and 2100, respectively.

Conclusion:

We found a higher prevalence of dementia and MCI than most previous studies. The present prevalence and future projections are vital for preparing for future challenges to the healthcare system and the entire society.

中文翻译：

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对挪威 70 岁及以上人群样本中轻度认知障碍、痴呆及其亚型的当前和未来患病率估计：HUNT 研究

摘要

背景：

获得关于轻度认知障碍 (MCI) 和痴呆症流行病学的准确、最新信息势在必行。

客观的：

使用来自大型人群研究的数据确定挪威 MCI 和痴呆症的患病率。

方法：

 在 Trøndelag 健康研究 (HUNT4) 的第四波中，所有 70 + 岁，n = 19,403 的人都被邀请参加 HUNT4 70 + 研究。受过培训的卫生人员在现场、家庭或疗养院使用认知测试对参与者进行评估。采访者还完成了一份关于疑似患有痴呆症的参与者的结构化护理人员问卷。临床专家根据 DSM-5 标准做出诊断。我们计算了权重数据的患病率，以确保人口代表性。

结果：

在可能的 19,403 人中，共有 9,930 (51.1%) 人参与，其中 9,663 人有足够的信息进行分析。痴呆和 MCI 的标准化患病率分别为 14.6%（95% 置信区间 (CI) 13.9-15.4）和 35.3%（95% CI 34.3-36.4）。痴呆症在女性中更为普遍，而 MCI 在男性中更为普遍。最普遍的痴呆亚型是阿尔茨海默病 (57%)。通过添加从同一地区 70 岁以下人群的研究中收集的数据，我们估计 2020 年挪威有 101,118 名痴呆症患者，预计到 2050 年和 2100 年分别增加到 236,789 和 380,134 人。

结论：

我们发现痴呆和 MCI 的患病率高于之前的大多数研究。目前的流行情况和未来的预测对于为医疗保健系统和整个社会的未来挑战做好准备至关重要。