Zika virus (ZIKV) has been detected in blood, urine, semen, cerebral spinal fluid, saliva, amniotic fluid, and breast milk. In most ZIKV infected individuals, the virus is detected in the blood to one week after the onset of symptoms and has been found to persist longer in urine and semen. To better understand virus dynamics, a prospective cohort study was conducted in Brazil to assess the presence and duration of ZIKV and related markers (viral RNA, antibodies, T cell response, and innate immunity) in blood, semen, saliva, urine, vaginal secretions/menstrual blood, rectal swab and sweat. The objective of the current manuscript is to describe the cohort, including an overview of the collected data and a description of the baseline characteristics of the participants. Men and women ≥ 18 years with acute illness and their symptomatic and asymptomatic household contacts with positive reverse transcriptase-polymerase chain reaction test for ZIKV in blood and/or urine were included. All participants were followed up for 12 months. From July 2017 to June 2019, a total of 786 participants (284 men, 502 women) were screened. Of these, 260 (33.1%) were enrolled in the study; index cases: 64 men (24.6%), 162 (62.3%) women; household contacts: 12 men (4.6%), 22 (8.5%) women. There was a statistically significant difference in age and sex between enrolled and not enrolled participants (p<0.005). Baseline sociodemographic and medical data were collected at enrollment from all participants. The median and interquartile range (IQR) age was 35 (IQR; 25.3, 43) for men and 36.5 years (IQR; 28, 47) for women. Following rash, which was one of the inclusion criteria for index cases, the most reported symptoms in the enrollment visit since the onset of the disease were fever, itching, arthralgia with or without edema, non-purulent conjunctivitis, headache, and myalgia. Ten hospitalizations were reported by eight patients (two patients were hospitalized twice) during follow up, after a median of 108 days following symptom onset (range 7 to 266 days) and with a median of 1.5 days (range 1 to 20 days) of hospital stay. A total of 4,137 visits were performed, 223 (85.8%) participants have attended all visits and 37 (14.2%) patients were discontinued.

寨卡病毒 (ZIKV) 已在血液、尿液、精液、脑脊液、唾液、羊水和母乳中检测到。在大多数 ZIKV 感染者中，病毒在症状出现一周后在血液中被检测到，并且被发现在尿液和精液中持续时间更长。为了更好地了解病毒动态，在巴西进行了一项前瞻性队列研究，以评估 ZIKV 和相关标志物（病毒 RNA、抗体、T 细胞反应和先天免疫）在血液、精液、唾液、尿液、阴道分泌物中的存在和持续时间/ 经血、直肠拭子和汗液。当前手稿的目的是描述队列，包括收集数据的概述和参与者基线特征的描述。包括 ≥ 18 岁患有急性疾病的男性和女性以及他们的有症状和无症状的家庭接触者，其血液和/或尿液中的 ZIKV 逆转录酶-聚合酶链反应检测呈阳性。对所有参与者进行了为期 12 个月的随访。从 2017 年 7 月到 2019 年 6 月，共有 786 名参与者（284 名男性，502 名女性）接受了筛查。其中，260 人（33.1%）参加了研究；指示病例：64 名男性（24.6%），162 名（62.3%）女性；家庭接触者：12 名男性（4.6%），22 名（8.5%）女性。已注册和未注册参与者的年龄和性别存在统计学差异（p<0.005）。在所有参与者登记时收集基线社会人口学和医学数据。男性的中位和四分位距 (IQR) 年龄为 35 岁 (IQR; 25.3, 43)，女性为 36.5 岁 (IQR; 28, 47)。出疹后，这是指标病例的纳入标准之一，自疾病发作以来，登记就诊中报告最多的症状是发热、瘙痒、伴有或不伴有水肿的关节痛、非化脓性结膜炎、头痛和肌痛。在症状出现后的中位时间为 108 天（范围为 7 至 266 天）和中位时间为 1.5 天（范围为 1 至 20 天）的随访期间，八名患者（两名患者两次住院）报告了 10 次住院治疗停留。总共进行了 4,137 次就诊，223 名 (85.8%) 参与者参加了所有就诊，37 名 (14.2%) 患者停止了治疗。头痛和肌痛。8 名患者（2 名患者住院 2 次）报告了 10 次住院，在症状发作后的中位时间为 108 天（范围为 7 至 266 天）和中位住院时间为 1.5 天（范围为 1 至 20 天）之后停留。总共进行了 4,137 次就诊，223 名 (85.8%) 参与者参加了所有就诊，37 名 (14.2%) 患者停止了治疗。头痛和肌痛。8 名患者（2 名患者住院 2 次）报告了 10 次住院，在症状发作后的中位时间为 108 天（范围为 7 至 266 天）和中位住院时间为 1.5 天（范围为 1 至 20 天）之后停留。总共进行了 4,137 次就诊，223 名 (85.8%) 参与者参加了所有就诊，37 名 (14.2%) 患者停止了治疗。