Polycystic kidney disease (PKD) is a common genetic disorder that results in a proliferating and enlarging cyst and ultimately leads to loss of kidney function. Because an enlarged cyst is a primary factor for limited kidney function, the large cyst is surgically removed by laparoscopic deroofing or sclerosant. This a relatively nascent treatment method entails complications and sometimes fail due to the cyst fluid refilling and infection. This study proposes using a more stable and effective polidocanol foam with glycerol and Rose Bengal (GRP form) to prevent cyst regeneration and irritation, which is caused by the required body movement during the treatment. Specifically, the foam retention time and viscosity were increased by adding glycerol up to 10% (w/v). The GRP form inhibited cellular proliferation and disrupted cellular junctions, e-cadherin, and cyst formation, demonstrated by the LDH, Live and Dead, and re-plating culture assays. The GRP foam was shown to be a safe and effective treatment as a commercial grade polidocanol foam form by an in vivo study in which subcutaneously injected mice injected with commercial 3% polidocanol, and the GRP foam showed no difference in inflammation. Thus, this study provides an advanced polidocanol form by adding glycerol and Rose-Bengal to help existing sclerotherapy.

多囊肾疾病（PKD）是一种常见的遗传疾病，会导致囊肿增生和扩大，并最终导致肾功能丧失。由于肿大的囊肿是限制肾功能的主要因素，因此可通过腹腔镜除皱术或硬化剂手术切除大囊肿。这种相对新生的治疗方法引起并发症，并且有时由于囊肿液的补充和感染而失败。这项研究建议使用更稳定，更有效的多多酚醇泡沫以及甘油和玫瑰红（GRP形式），以防止由治疗期间所需的身体运动引起的囊肿再生和刺激。具体而言，通过添加甘油至多10％（w / v）来增加泡沫保留时间和粘度。GRP形式抑制细胞增殖并破坏细胞连接，E-钙粘蛋白和囊肿的形成，通过LDH，“生与死”和重新铺板培养测定法得到证实。GRP泡沫已被证明是一种安全有效的治疗方法，可作为商业级的多酚醇泡沫形式。在体内研究中，皮下注射的小鼠注射了市售的3％polidocanol，而GRP泡沫在炎症方面没有差异。因此，本研究通过添加甘油和Rose-Bengal提供了一种先进的多多卡醇形式，以帮助现有的硬化疗法。