Mtr4 is a Ski2-like RNA helicase that plays a central role in RNA surveillance and degradation pathways as an activator of the RNA exosome. Multiple crystallographic and cryo-EM studies over the past 10 years have revealed important insight into the Mtr4 structure and interactions with protein and nucleic acid binding partners. These structures place Mtr4 at the center of a dynamic process that recruits RNA substrates and presents them to the exosome. In this review, we summarize the available Mtr4 structures and highlight gaps in our current understanding.

中文翻译：

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Mtr4 RNA解旋酶结构和相互作用

Mtr4 是一种类似 Ski2 的 RNA 解旋酶，作为 RNA 外泌体的激活剂，在 RNA 监视和降解途径中发挥着核心作用。过去 10 年的多项晶体学和冷冻 EM 研究揭示了对 Mtr4 结构以及与蛋白质和核酸结合伙伴的相互作用的重要见解。这些结构将 Mtr4 置于招募 RNA 底物并将其呈递给外泌体的动态过程的中心。在这篇评论中，我们总结了可用的 Mtr4 结构并突出了我们目前理解中的差距。