Abstract

Cardiac patches are used to recover the damaged cardiac tissues. In this research, cardiac patch was fabricated using electrospinning method and evaluated for its physicochemical properties. The patch was made from polyurethane (PU) added with cobalt nanoparticles (CoNPs) which is synthesized through green route via green tea containing polyphenols. The 0.5 mg/mL, 1.0 mg/mL and 1.5 mg/mL cobalt salt concentrations mixed with green tea solution produced different nanoparticles morphology. Further, synthesized CoNPs with cobalt salt concentration of 1.5 mg/mL was incorporated in the PU using electrospinning method. The developed patches with higher CoNPs ratio exhibited smaller diameter compared to PU as observed using SEM. PU- CoNPs patch rendered hydrophilic surface with lower ratio of CoNPs. On the other hand, higher ratio of CoNPs exhibited enhanced strength compared to the pristine PU. Patches with the improved physicochemical properties and mechanical strength can be exploited for cardiac applications.

摘要

心脏贴片用于恢复受损的心脏组织。在这项研究中，心脏贴片采用静电纺丝法制造，并对其物理化学性质进行了评估。该贴片由聚氨酯 (PU) 制成，并添加了钴纳米粒子 (CoNPs)，钴纳米粒子 (CoNPs) 通过绿色路线合成绿茶含有多酚。0.5 mg/mL、1.0 mg/mL和1.5 mg/mL钴盐浓度与绿茶溶液混合产生不同的纳米颗粒形态。此外，使用静电纺丝法将钴盐浓度为 1.5 mg/mL 的合成 CoNPs 掺入到 PU 中。与使用 SEM 观察到的 PU 相比，具有更高 CoNPs 比率的开发贴片显示出更小的直径。PU-CoNPs 贴片以较低比例的 CoNPs 呈现亲水表面。另一方面，与原始 PU 相比，较高比例的 CoNPs 表现出增强的强度。具有改善的物理化学性质和机械强度的贴片可用于心脏应用。