Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by the loss of both upper and lower motor neurons. Studies using various magnetic resonance imaging (MRI) analytical approaches have consistently identified significant precentral abnormalities in ALS, whereas their structural and functional underpinnings remain poorly understood.

中文翻译：

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肌萎缩侧索硬化中前区异常的结构和功能基础

肌萎缩侧索硬化 (ALS) 是一种进行性神经退行性疾病，其特征是上、下运动神经元均丧失。使用各种磁共振成像 (MRI) 分析方法的研究一致确定了 ALS 的显着中央前异常，而其结构和功能基础仍然知之甚少。