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Novel beeswax-chitosan/Zinc-hydroxyapatite biocomposite porous scaffolds: Preparation and biological evaluation
Journal of Science: Advanced Materials and Devices ( IF 7.382 ) Pub Date : 2021-01-06 , DOI: 10.1016/j.jsamd.2021.01.001
K. Manivannan , G. Jaganathan , M. Aboobucker Sithique

We developed a novel BW-CS/ZnHA biocomposite utilizing Beeswax-Chitosan and Zinc-hydroxyapatite nanoparticles (ZnHAP). The uniformed mixture of beeswax-chitosan and ZnHAP was freeze-dried to get a porous biocomposite. The fabricated biocomposite was characterized using FTIR, XRD, and SEM. Moreover, the antibacterial, swelling, biodegradations, viability, and cell proliferation capacity of the fabricated biocomposite was assessed. The biocomposite demonstrated upgraded swelling and antibacterial activity. The addition of ZnHAP accomplished the antibacterial activity. Biocompatibility studies were carried out using osteoblast cells and thus we proved the non-toxic nature of the biocomposite. Osteoblast cell adhesion investigations demonstrated that the cells were appended and infiltrated into the inside of the biocomposite. The obtained results encourage the use of these bandages for various types of wounds with infection and exudates.



中文翻译:

新型蜂蜡-壳聚糖/锌-羟基磷灰石生物复合多孔支架的制备及生物学评价

我们开发了一种利用蜂蜡-壳聚糖和锌-羟基磷灰石纳米粒子(ZnHAP)的新型BW-CS / ZnHA生物复合材料。将蜂蜡-壳聚糖和ZnHAP的均匀混合物冷冻干燥,得到多孔的生物复合材料。使用FTIR,XRD和SEM对制备的生物复合材料进行了表征。此外,评估了所制造的生物复合材料的抗菌性,溶胀性,生物降解性,生存力和细胞增殖能力。该生物复合材料显示出更高的溶胀和抗菌活性。ZnHAP的添加完成了抗菌活性。使用成骨细胞进行了生物相容性研究,因此我们证明了该生物复合物的无毒性质。成骨细胞粘附研究表明,细胞被附着并浸入生物复合材料的内部。

更新日期:2021-01-06
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