Owing to their functional diversity, the Mas-related G-protein-coupled receptor (Mrgpr) family has a role in both itch and pain modulation. While primarily linked to pruritis, Mrgprs were originally characterized in small-diameter nociceptive neurons of dorsal root ganglia (DRG) and trigeminal ganglia. This review will focus on the role Mrgpr’s have in pain physiology, discussing recent discoveries as well as how Mrgpr’s may provide a new target for the treatment of pathological pain.

中文翻译：

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Mrgprs在疼痛中的作用

由于其功能多样性，与Mas相关的G蛋白偶联受体（Mrgpr）家族在瘙痒和疼痛调节中均具有作用。虽然主要与瘙痒有关，但Mrgprs最初以背根神经节（DRG）和三叉神经节的小直径伤害感受神经元为特征。本文将重点讨论Mrgpr在疼痛生理学中的作用，讨论最新发现以及Mrgpr如何为病理性疼痛提供新的靶标。