With worsening air pollution brought by global social development, the prevalence of allergic diseases has increased dramatically in the past few decades. The novel Lck/yes-related protein tyrosine kinase (Lyn) belongs to the Src kinase family (SFK) and plays a pivotal role in the pathogenesis of inflammation, tumor, and allergy. This signaling molecule is vital in the IgE/FcεRI signaling pathway that regulates allergy. The Lyn–FcεRIβ interaction is essential for mast cell activation. The signaling pathway of Lyn has become the focus of immune, inflammatory, tumor, and allergy research. This molecule has positive and negative regulatory effects, which have attracted researchers' attention. This paper reviews the basic characteristics of Lyn and its regulatory mechanism and role in tumor and other diseases, specifically in allergies.

随着全球社会发展带来的日益严重的空气污染，在过去的几十年中，过敏性疾病的流行急剧增加。新型的Lck / yes相关蛋白酪氨酸激酶（Lyn）属于Src激酶家族（SFK），在炎症，肿瘤和过敏的发病机理中起关键作用。该信号分子在调节过敏的IgE /FcεRI信号通路中至关重要。Lyn-FcεRIβ相互作用对于肥大细胞激活至关重要。Lyn的信号通路已成为免疫，炎症，肿瘤和过敏研究的重点。该分子具有正调节作用和负调节作用，引起了研究人员的注意。本文综述了Lyn的基本特征及其在肿瘤和其他疾病（尤其是过敏性疾病）中的调控机制和作用。