All aspects of each protein existence in the eukaryotic cells, starting from the pre-translation events, through translation, multiple different post-translational modifications, functional life and eventual proteostatic removal after loss of functionality and changes in physico-chemical properties, can be collectively called the proteodynamics. With aging, passing of time as well as accumulating effects of exposures, interactions and wearing-off lead to problems at each of the above mentioned stages, eventually leading to general malfunction of the proteome. This work briefly reviews and summarizes current knowledge concerning this important topic.

中文翻译：

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真核细胞的蛋白质动力学和老化

真核细胞中存在的每种蛋白质的所有方面，从翻译前事件开始，到翻译、多种不同的翻译后修饰、功能寿命和功能丧失和物理化学性质变化后的最终蛋白质稳态去除，可以统称为称为蛋白质动力学。随着年龄的增长、时间的流逝以及暴露、相互作用和磨损的累积影响，上述每个阶段都会出现问题，最终导致蛋白质组的普遍故障。这项工作简要回顾和总结了有关这一重要主题的当前知识。